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AssigneesWake Forest University, Wake Forest University Health Sciences
InventorsMark E. Welker, Emmanuel C. Opara, Surya Banks
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A novel chemically modified alginate hydrogel has been developed which combines an aromatic compound with a carbohydrate, where the aromatic compound is one or more amines combined with an alginate. The chemical structure of alginate is modified using different amines and different methods, including: (1) covalently bonding aminoethyl benzoic acid to the alginate backbone, and (2) oxidizing the vicinal diol in the alginate chain to an aldehyde before coupling to aminoethyl benzoic acid. Alternatively, the combined aromatic compound and carbohydrate can be a dopamine combined with the alginate. The chemically modified alginate and the methods used can be utilized to encapsulate a variety of bioactive substances for oral delivery in humans and animals, including, but not limited to: (i) drugs, medicines, enzymes, proteins, hormones, and vaccines, (ii) vitamins, minerals, micronutrients and/or other dietary supplements, (iii) probiotics and/or other microorganisms, (iv) cells, cell parts, and/or other biological materials, and/or (v) other bioactive substances.
A composition comprising a substance wherein said substance comprises one or more (i) drugs, medicines, enzymes, proteins, hormones, vaccines, vitamins, minerals, micronutrients and/or other dietary supplements, (ii) probiotics and/or other microorganisms, (ii) cells, cell parts, and/or other biological materials, and/or (iii) other bioactive compounds or substances,
A method of making proteins, micronutrients, dietary supplements and/or probiotics more bioavailable to an individual in need of said proteins, micronutrients, dietary supplements and/or probiotics by administering to said individual said dietary supplements and/or probiotics encapsulated in a modified alginate, said modified alginate being modified by the incorporation of covalently linked dopamine, 4(2-ethylamino)benzoic acid, 4-aminomethyl benzene sulfonamide substituents, or 4-aminoethyl benzene sulfonamide substituents.
A method of preparing an aromatic alginate, said method comprising reacting an alginate with an aromatic substituent, said aromatic substituent comprising one or more of a dopaminic substituent, a 4(2-ethylamino)phenolic substituent, a 4(2-ethylamino)benzoic acid substituent, a 4(2-ethylamino)anilinic substituent, a 4(2-ethylamino)toluenic substituent, a 4-aminomethyl benzene sulfonamide, a 4-aminoethyl benzene sulfonamide or mixtures thereof.
A method of delivering a protein, micronutrient, dietary supplement or probiotic to an individual in need thereof, said method comprising administering to said individual a composition that comprises a modified carbohydrate, said modified carbohydrate comprising a modified alginate, that has been modified by an aromatic substitute, said aromatic substituent comprising one or more of a dopaminic substituent, a phenolic substituent, a benzoic acid substituent, an anilinic substituent, an amino sulfonamide benzene substituent or mixtures thereof.
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