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US 2018/0000742 A1Published application
Pharmaceutical Composition for Oral Insulin Administration Comprising a Tablet Core and a Polyvinyl Alcohol Coating
OwnerLars Hovgaard, Hanne Refsgaard +3inventors
InventorsLars Hovgaard, Hanne Refsgaard, Thomas Boerglum Kjeldsen, Peter Madsen, Giustino Di Pretoro
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Abstract
The present invention relates to a solid oral insulin composition comprising a salt of capric acid which enhances the bioavailability and/or the absorption of said acylated insulin in combination with a polyvinyl alcohol coating, which is soluble in aqueous media independent of pH.
Claims16
A pharmaceutical composition comprising one or more tablet core and optionally a polyvinyl alcohol coating, wherein said one or more tablet core comprises a salt of a medium-chain fatty acid and an acylated insulin,
- wherein said acylated insulin comprises an additional disulfide bridge, or, wherein said acylated insulin is a protease stabilised insulin comprising a linker and a fatty acid or fatty diacid side chain having 14-22 carbon atoms and optionally comprises an additional disulfide bond.
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Dependencies are inferred from the claim text.