Novel pharmaceutical composition
AssigneesDaewoong Pharmaceutical Co., Ltd., Bio-Synectics Inc.
InventorsSanghee KIM, Hee Chul CHANG, Ji Hoon JUNG
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Abstract
Disclosed herein a pharmaceutical composition comprising aprepitant a pharmaceutically acceptable salt thereof; at least one hydrocarbon derivative selected from among a fatty acid of 14 to 18 carbon atoms, and a fatty alcohol of 14 to 18 carbon atoms; and at least one selected from among polyoxyethyelene-type nonionic surfactant, sucrose fatty acid ester, and Macrogol 15 hydroxystearate. The pharmaceutical composition of the present disclosure can release aprepitant or a pharmaceutically acceptable salt thereof to effectively exert the pharmaceutical efficacy, and can be dissolved in a fasted state simulated gastrointestinal fluid so that it can be useful for study on the in vivo pharmacokinetic behavior of aprepitant.
Claims12
A pharmaceutical composition, comprising:
- aprepitant or a pharmaceutically acceptable salt thereof;
- at least one hydrocarbon derivative selected from among a fatty acid of 14 to 18 carbon atoms, and a fatty alcohol of 14 to 18 carbon atoms;
- and
- at least one surfactant selected from among a polyoxyethylene-type nonionic surfactant, a sucrose fatty acid ester, and Macrogol 15 hydroxystearate.
Dependencies are inferred from the claim text.