Injectable aggregates for joint and soft tissue distress
AssigneeVisgo Therapeutics, Inc.
InventorsJeanne M. Bertonis, Paul Higham, Pamela A. Hay
Life of this patent
Estimating the term…
Abstract
Aggregates formed from one or both of chitosan and hyaluronan, suspended or otherwise dispersed in a liquid carrier are useful for treating joint or muscle distress in a subject, where the composition may include one or more pharmaceutically active agents and the composition in locally delivered to the joint or muscle by, for example, injection.
Claims15
A composition comprising particles, the particles comprising crosslinked chitosan having amino (—NH2) groups, and an active pharmaceutical ingredient (API) incorporated into the particles, the particles having a diameter of greater than 25 microns and less than 100 microns, wherein the crosslinked chitosan is the reaction product of a crosslinking agent and a chitosan having a degree of deacetylation (DDA) of greater than 75% and less than 95%.
A method of delivering a particle into a synovial fluid and a synovium of a subject to provide a depot for sustained release of an active pharmaceutical agent (API) from the particle, the method comprising:
- a. providing a liquid composition comprising particles, the particles comprising crosslinked chitosan having amino (—NH2) groups, and an active pharmaceutical agent (API) incorporated into the particles, the particles having a diameter of greater than 25 microns and less than 100 microns, wherein the crosslinked chitosan is the reaction product of a crosslinking agent and a chitosan having a degree of deacetylation (DDA) of greater than 75% and less than 95%;
- b. providing a syringe containing the liquid composition, the syringe having a needle in the range of 18-27 gauge;
- and
- c. intra-articularly injecting the liquid composition through the needle and into a subject in need thereof.
Dependencies are inferred from the claim text.