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US 2018/0000729 A1Published application
Depot formulations
AssigneesDurect Corporation, Santen Pharmaceutical Co., Ltd.
InventorsWilma TAMRAZ, Huey-Ching SU, WeiQi LIN, Kazuhito YAMADA, Naoki MATSUMOTO, Sreenivasu MUDUMBA, Komei OKABE
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Abstract
Pharmaceutical compositions comprising an active pharmaceutical ingredient, a high viscosity liquid carrier material, a hydrophobic solvent, and a hydrophilic solvent are disclosed. Also disclosed are methods of manufacturing and using the compositions. The compositions are suitable for use, e.g., as depot formulations.
Claims38
A composition comprising:
- an active pharmaceutical ingredient;
- a high viscosity liquid carrier material (HVLCM);
- a first hydrophobic solvent;
- and
- a hydrophilic solvent;
- wherein:
- (i) the active pharmaceutical ingredient comprises sirolimus;
- and/or
- (ii) the composition is a solution at 25° C. and 1 atmosphere and/or the composition has a viscosity ranging from about 1 cP to about 150 cP at 25° C. and 1 atmosphere.
6 more elements
A method of treating a subject afflicted with an eye condition, the method comprising:
- administering a composition to an eye of a subject in need thereof, wherein the composition comprises an effective amount of an active pharmaceutical ingredient capable of treating the eye condition, the composition comprising:
- an active pharmaceutical ingredient;
- a high viscosity liquid carrier material (HVLCM);
- a first hydrophobic solvent;
- and
- a hydrophilic solvent.
3 more elements
Dependencies are inferred from the claim text.