Systems and methods for heart valve therapy

A method of using a prosthetic mitral valve system, comprising:

• advancing a valve assembly of the prosthetic mitral valve system toward an annulus of a native mitral valve, the valve assembly comprising:
• a frame member defining an outer profile and an interior frame member space;
• and
• an occluder disposed within the interior frame member space, the occluder having an open configuration and a closed configuration,
• wherein the frame member comprises a proximal end frame portion and a distal end frame portion, wherein an outer periphery of the distal end frame portion comprises a generally flat region and a generally round region, and wherein at least some portions of the generally flat region extend toward the interior frame member space;
• and
• anchoring the valve assembly at the native mitral valve such that the generally flat region is adjacent to an anterior native leaflet of the native mitral valve.

A prosthetic mitral valve system that is implantable at a native mitral valve, the prosthetic mitral valve system comprising:

• an anchor assembly defining an interior anchor assembly space and a longitudinal axis, the anchor assembly comprising an expandable anchor frame including a hub and a sub-annular support arm extending from the hub, wherein the sub-annular support arm extends to an anchor foot having a surface configured for engagement with a sub-annular gutter of the native mitral valve;
• and
• a valve assembly comprising:
• an expandable valve frame defining an outer profile and an interior frame member space;
• and
• an occluder disposed within the interior frame member space, the occluder having an open configuration and a closed configuration,
• wherein the valve assembly is releasably engageable with the anchor assembly within the interior anchor assembly space, and wherein a distance measured parallel to the longitudinal axis from a distal-most end of the anchor assembly to the surface is at least 14 millimeters.