Diagnostic classification of corneal shape abnormalities
AssigneeOregon Health & Science University
InventorsMaolong Tang, Yan Li, David Huang
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Abstract
Disclosed are systems and methods for characterizing corneal shape abnormalities. These methods may be used to differentiate corneas having subclinical keratoconus from other conditions which cause distortion of corneal shape, including warpage of the cornea due to contact lens wear. Also disclosed is classification scheme to aid diagnosis of corneal conditions and thereby guide clinical decision making regarding patient treatment. This classification scheme is based on computed properties of corneal shape, is amenable to automation, and may be implemented in an integrated system or provided in the form of software encoded on a computer-readable medium.
Claims26
A computer-based method of classifying corneal shape abnormalities, said method comprising:
- generating a corneal topography map of a subject's cornea;
- generating an epithelial thickness map of the subject's cornea;
- calculating an epithelial thickness pattern standard deviation (PSD) value based on the epithelial thickness map;
- calculating a warpage index based on the corneal topography map and the epithelial thickness map;
- and
- classifying the subject's cornea using the epithelial PSD value and the warpage index.
A system for classifying corneal shape abnormalities, the system comprising:
- an optical coherence tomography (OCT) system to acquire an OCT dataset for a cornea;
- a logic subsystem;
- and
- a data holding subsystem comprising machine-readable instructions stored thereon that are executable by the logic subsystem to:
- generate a corneal topography map of the cornea;
- generate an epithelial thickness map of the cornea from the OCT dataset;
- calculate an epithelial thickness pattern standard deviation (PSD) value based on the epithelial thickness map;
- calculating a warpage index based on the corneal topography map and the epithelial thickness map;
- and
- classify the cornea using the epithelial PSD value and the warpage index.
Dependencies are inferred from the claim text.