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US 2017/0370953 A1Published application
Microfluidic flow assay and methods of use
AssigneeColorado School of Mines
InventorsKeith B. Neeves, Abimbola Onasoga
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Abstract
A method for evaluating a blood product of an individual are provided. Specifically, a method to utilize a microfluidic flow assay, which includes a substrate surface comprising lipid coated particles and microfluidic channels through which a blood product can flow. The lipid coated particles comprise functional molecules that can induce or inhibit the coagulation cascade.
Claims20
A method for evaluating a blood product of an individual, comprising:
- a. perfusing the individual's blood product over a microfluidic device under flow conditions to contact the blood product with a functional molecule of a plurality of coated lipid particles, wherein the microfluidic device, comprises at least one microfluidic channel;
- and at least one substrate surface provided in the at least one microfluidic channel, wherein the at least one substrate surface comprises a plurality of lipid coated particles immobilized on the substrate surface, wherein the plurality of lipid coated particles comprises at least one functional molecule, wherein the at least one functional molecule induces coagulation;
- and
- b. detecting one or more coagulation products associated with the at least one functional molecule of the plurality of the lipid coated particles.
1 more element
Dependencies are inferred from the claim text.