Methods to identify candida species from patient cultures using raman spectrometry
OwnerNitin Shashikant CHOUTHAIinventor
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Abstract
Methods to identify fungal or bacterial species using Raman spectrometry, among other techniques are described. The identification can occur from samples taken directly from cultures grown from a patient sample. The methods significantly decrease the time required to identity a fungal or bacterial species in a clinical setting, allowing more effective treatments, especially in low birth weight neonates and immunocompromised individuals.
Claims21
A method of identifying a fungal or bacterial species comprising:
- (a) establishing a database of characteristic curves of fungal or bacterial species;
- (b) performing a spectral analysis method on a sample obtained from a subject and obtaining corresponding characteristic curves;
- and (c) searching the database of step (a) for a match to the characteristic curves obtained in step (b), and (d) identifying a fungal or bacterial species in the sample.
A method comprising testing a sample obtained from a subject suspected of suffering from a Candida infection for the presence of a spectral curve associated with a Candida species;
- assessing obtained spectral curves for matching to spectral curves of Candida species;
- identifying a Candida species based on the assessing, if a match is present.
A method comprising obtaining a sample from a lowbirth weight neonate accumulating spectral data from the sample;
- identifying a spectral feature that is indicative of infection by a Candida species;
- directing a course of antifungal treatment based on the identifying.
Dependencies are inferred from the claim text.