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AssigneeHyperstem SA
InventorsAngelo Luigi Vescovi, Elena Binda
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The described invention relates to a pharmaceutical composition comprising a therapeutically effect amount of a therapeutic agent, wherein the therapeutic agent is effective (1) to reduce tumor growth, migration, invasion or a combination and (2) improve subject survival relative to a control. The described invention also relates to a method of treating a subject with a tumor, the method comprising: (1) providing a pharmaceutical composition; and (2) administering the pharmaceutical composition, wherein the composition comprises a therapeutically effective amount of a therapeutic agent which is effective to reduce tumor growth, migration, invasion or a combination. The method may further comprise preparing therapeutic agent and preparing the pharmaceutical composition. The therapeutic agents include but are not limited to Wnt5a derivative peptides or Wnt5a antagonists or Wnt5a blocking antibody. The tumor comprises a population of cancer stem cells.
A pharmaceutical composition to treat a solid tumor comprising a population of tumor-propagating cells with stem-like characteristics (TPCs) in a subject comprising a therapeutic amount of a therapeutic agent and a pharmaceutically acceptable carrier, wherein the therapeutic agent is a peptide derivative of Wnt5a,
The pharmaceutical composition according to claim 2, wherein the solid tumor is selected from the group consisting of a brain tumor, a colon tumor, a prostate tumor, a breast tumor, a lung tumor, a skin tumor, a liver tumor, a bone tumor, an ovary tumor, a pancreas tumor, a head tumor, a neck tumor, a nerve tumor and a lymphoma.
A method for treating a solid tumor comprising a population of tumor-propagating cells with stem-like characteristics (TPCs) in a subject comprising administering to the subject a pharmaceutical composition comprising a therapeutic amount of a therapeutic agent and a pharmaceutically acceptable carrier, wherein the therapeutic agent is a peptide derivative of Wnt5a,
A pharmaceutical composition for use in treating a solid tumor comprising a population of tumor-propagating cells with stem-like characteristics (TPCs) in a subject comprising a therapeutic amount of a therapeutic agent and a pharmaceutically acceptable carrier, wherein the therapeutic agent is a peptide derivative of Wnt5a,
Use of a pharmaceutical composition in the manufacture of a medicament for treating a solid tumor comprising a population of tumor-propagating cells with stem-like characteristics (TPCs) in a subject comprising administering to the subject a pharmaceutical composition comprising a therapeutic amount of a therapeutic agent and a pharmaceutically acceptable carrier, wherein the therapeutic agent is a peptide derivative of Wnt5a,
Dependencies are inferred from the claim text.