Osmotic delivery device comprising an insulinotropic peptide and uses thereof

A method of manufacturing an osmotic delivery device comprising, loading a suspension formulation into a reservoir of the osmotic delivery device,

• the suspension formulation comprising:
• a particle formulation comprising:
• an insulinotropic peptide, an antioxidant, and a buffer, wherein the insulinotropic peptide is at least one of exenatide, a derivative of exenatide, and an analogue of exenatide;
• and
• a non-aqueous, single-phase suspension vehicle that comprises about 20 wt % to about 60 wt % solvent and about 80 wt % to about 40 wt % pyrrolidone polymer, the suspension vehicle having a viscosity from 5,000 poise to 50,000 poise at 33° C.;
• wherein:
• the solvent is at least one of lauryl lactate, lauryl alcohol, and benzyl benzoate;
• 30 to 90% by weight of the particle formulation is the insulinotropic peptide;
• the particle formulation has a wt % ratio of insulinotropic peptide to antioxidant of 2.5/1 to 10/1;
• and the particle formulation is dispersed in the suspension vehicle.