Induction of tolerance in lung allograft transplantation
AssigneeWashington University
InventorsAlexander Sasha Krupnick, Daniel Kreisel, Andrew Gelman
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Abstract
The present disclosure relates to methods of inducing tolerance to lung allograft transplantation. These methods comprise increasing suppressor CD8+ T cells and/or suppressing deleterious CD8+ and CD4+ T cells.
Claims18
A method of inducing tolerance to a lung allograft in a subject, the method comprising suppressing an alloimmune response to the lung allograft in the subject by administering CD8+ T cells to the lung allograft in an amount sufficient to suppress the alloimmune response in the subject.
A method of inducing tolerance to a lung allograft in a subject by increasing the level of nitric oxide in the lung allograph of the subject, wherein the level of nitric oxide is increased by administering CD8+ T cells to the lung allograft.
A method of administering central memory T cells to an ex vivo graft, the method comprising,
- a. obtaining immune cells from a subject;
- b. culturing the immune cells in vitro;
- c. generating central memory T cells by stimulating the immune cells in vitro;
- and
- d. administering the central memory cells to the graft.
Dependencies are inferred from the claim text.