Controlled release from particles encapsulated by molecular layer deposition

A slow-release material (1) comprising particles (100), wherein the particles (100) comprise a core (110) comprising an active component (10) and a multi-layer shell (120), wherein the multi-layer shell (120) comprises a molecular layer deposition (MLD) multi-layer (1200), wherein the active component comprises one or more of a pharmaceutical compound and a nutraceutical compound, for use in the treatment of a disease, and wherein each layer (121) of the multi-layer shell (120) comprises a group defined by formula (I):

• wherein R1, R2, R3, and R4 are independently selected from the group consisting of a carbon comprising group, wherein Z1 and Z2 are each independently selected from an oxygen or nitrogen comprising group, and wherein R2 is optionally present.

A reactor (1000) for fluidizing particles (110) comprising a diameter (d1) selected from the range of 1 nm-2 mm, wherein the reactor (1000) comprises a first inlet (1001) for introduction of one or more reactants in the gas phase, wherein the reactor (1000) further comprises a vibration generator (1600) configured to subject the reactor (1000) to a vibration having a frequency selected from the range of 1-200 Hz, wherein the reactor (1000) further comprises a second inlet (1002) for a gas, configured to provide during operation a counter flow relative to a flow introduced in the reactor (1000) via the first inlet (1001).

A core-shell particle (100), comprising a core (110) comprising an active component (10) and a shell (120), wherein the shell (120) comprises a plurality of polymers, with each polymer attached with one end to the core, and each polymer comprises a plurality of groups defined by formula (I):

• wherein R1, R2, R3, and R4 are independently selected from the group consisting of a carbon comprising group, wherein Z1 and Z2 are each independently selected from an oxygen or nitrogen comprising group, and wherein R2 is optionally present.