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US 2017/0365053 A1Published application
Scoring of tumor infiltration by lymphocytes
AssigneeThe Institute of Cancer Research: Royal Cancer Hos
InventorYinyin Yuan
Life of this patent
Estimating the term…
Abstract
A method of providing a prognosis in a cancer patient comprising analysing a tumour image to calculate a metric of immune infiltration for the tumour, and a method of analysing a tumour image.
Claims13
A method of measuring immune infiltration in a tumour, the method comprising:
- providing an image of the tumour in which lymphocytes and cancer cells have been identified;
- obtaining a lymphocyte-to-cancer measurement for each lymphocyte;
- classifying a subset of the lymphocytes as intra-tumour lymphocytes according to their lymphocyte-to-cancer measurement;
- quantifying the intra-tumour lymphocytes and the cancer cells in the tumour image;
- calculating the intra-tumour lymphocyte ratio (ITLR) as the ratio of intra-tumour lymphocytes to cancer cells, wherein the ITLR is a measurement of immune infiltration in the tumour.
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Dependencies are inferred from the claim text.