Methods of Treating and Prognosing Nonhematopoietic Malignant Tumors
AssigneeMemorial Sloan Kettering Cancer Center
InventorsLarry Norton, Ross Levine, Maria Kleppe, Elizabeth Comen
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Abstract
Provided herein are methods of treating a nonhematopoietic malignant tumor in a patient and methods of prognosing a nonhematopoietic malignant tumor in a patient, comprising administering to the patient a therapeutically effective amount of an agent that preferentially kills or inhibits proliferation or activity of leukocytes relative to nonhematopoietic cells.
Claims70
A method of treating a nonhematopoietic malignant tumor in a patient comprising administering to the patient a therapeutically effective amount of a first agent that preferentially kills or inhibits proliferation or activity of leukocytes relative to nonhematopoietic cells.
A method of prognosing a nonhematopoietic malignant tumor in a patient comprising determining whether tumor infiltrating leukocytes of the nonhematopoietic malignant tumor have one or more somatic gene mutations, wherein if the tumor infiltrating leukocytes have one or more somatic gene mutations, then the patient is indicated to have a worse prognosis than if the tumor infiltrating leukocytes do not have the one or more somatic gene mutations.
Dependencies are inferred from the claim text.