Plasma autoantibody biomarkers for basal like breast cancer
OwnerJoshua LaBaer, Jie Wang +5inventors
InventorsJoshua LaBaer, Jie Wang, Ji Qiu, Garrick Wallstrom, Karen Anderson, Jin Park, Jonine Figueroa
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Abstract
Cancer patients make antibodies to tumor-derived proteins that are potential biomarkers for early detection. Twenty-eight antigens have been identified as potential biomarkers for the early detection of basal-like breast cancer (Tables 1, 2). Also, a 13-AAb classifier has been developed that differentiate patients with BLBC from healthy controls with 33% sensitivity at 98% specificity (Table 3).
Claims6
A method for detection of basal-like breast cancer in a patient sample harboring one or more antigens, comprising:
- detecting a tumor antigen biomarker in said patient sample, wherein the biomarker is selected from the antigens:
- P53 (TP53), NY-ESO-1 (CTAG1B), NY-ESO-2 (CTAG2), RNF216, PPHLN1, PIP4K2C, ZBTB16, TAS2R8, WBP2NL, DOK2, PSRC1, MN1, TRIM21, POU4F1, SSMEM1, LMO4, BCL2, KRT8, TSGA13, PVRL4, SNRK, DYRK3, RNF32, JUNB, KCNIP3, CCDC68, CSN3, TRAIP.
A basal-like breast cancer diagnostic test kit, comprising an antibody against a tumor antigen biomarker selected from the group consisting of:
- P53 (TP53), NY-ESO-1 (CTAG1B), NY-ESO-2 (CTAG2), RNF216, PPHLN1, PIP4K2C, ZBTB16, TAS2R8, WBP2NL, DOK2, PSRC1, MN1, TRIM21, POU4F1, SSMEM1, LMO4, BCL2, KRT8, TSGA13, PVRL4, SNRK, DYRK3, RNF32, JUNB, KCNIP3, CCDC68, CSN3, TRAIP, and a suitable detection agent.
A method for diagnosing basal-like breast cancer from a patient sample harboring one or more antigens, comprising:
- a) detecting a tumor antigen biomarker in said patient sample, wherein the biomarker is selected from the antigens:
- P53 (TP53), NY-ESO-1 (CTAG1B), NY-ESO-2 (CTAG2), RNF216, PPHLN1, PIP4K2C, ZBTB16, TAS2R8, WBP2NL, DOK2, PSRC1, MN1, TRIM21, POU4F1, SSMEM1, LMO4, BCL2, KRT8, TSGA13, PVRL4, SNRK, DYRK3, RNF32, JUNB, KCNIP3, CCDC68, CSN3, TRAIP;
- and
- b) comparing a detection result of step a) with a control.
Dependencies are inferred from the claim text.