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US 2017/0362613 A1Published application
Recombinant Host Cells For The Production Of 3-Hydroxypropionic Acid
AssigneeNovozymes A/S
InventorMonica TASSONE
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Abstract
Provided herein are recombinant host cells having an active 3-Hydroxypropionic Acid (3-HP) pathway wherein the host cells comprise a heterologous polynucleotide encoding a 3-hydroxypropionate dehydrogenase (3-HPDH). Also described are methods of using the recombinant cells to produce 3-HP and derivatives of 3-HP (e.g., acrylic acid).
Claims20
A recombinant yeast cell, comprising an active 3-HP pathway capable of producing 3-HP and a heterologous polynucleotide encoding a 3-hydroxypropionate dehydrogenase (3-HPDH), wherein the 3-HPDH comprises:
- (a) deletion of the N-terminal mitochondrial target sequence (MTS) corresponding to amino acids 2-16 of SEQ ID NO:
- 197, and
- (b) at least 80% sequence identity to amino acids 17-354 of SEQ ID NO:
- 197.
1 more element
Dependencies are inferred from the claim text.