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US 2017/0362571 A1Published application
Activated platelet composition with tunable growth factor level
AssigneeGeneral Electric Company
InventorsVasile Bogdan Neculaes, Juan Jose Becerra, Christine Angela Morton, Andrew Soliz Torres, Antonio Caiafa
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Abstract
Methods and systems for generating a tunable or customizable activated product composition are related. In certain embodiments, one or more of electric pulse parameters, flow rate, or sample container size are varied so as to generate the activated product composition. The activated product composition may be customized or optimized based for a particular patient or procedure.
Claims20
A system, comprising:
- a sample holder configured to accept at least one cuvette;
- pulse generating circuitry configured to generate one or more electrical pulses into a cuvette disposed in the sample holder;
- processing circuitry configured:
- to execute one or more processor executable routines;
- and
- to cause the pulse generating circuitry to generate the one or more electrical pulses;
- and
- a non-transitory computer-readable memory configured to store the one or more processor executable routines, wherein at least one of the one or more processor-executable routines is configured to cause the processor to:
- specify a set of electrical pulse parameters, wherein the set of electrical pulse parameters is associated with a growth factor profile of a plurality of growth factor profiles, the first growth factor profile comprising an adjustably controlled level of at least one growth factor released by one or more of platelets, red blood cells, or white blood cells, and wherein the level of the at least one growth factor is substantially equal to or larger than a level of growth factor obtained with a thrombin activation;
- configure the pulse generating circuitry to generate the one or more electrical pulses based on the specified set of electrical pulse parameters;
- and
- cause the pulse generating circuitry to expose the cuvette disposed in the sample holder to the specified set of electrical pulses, to generate an activated product composition having the growth factor profile.
9 more elements
An electric pulse generating system, comprising:
- a sample holder comprising at least two electrodes;
- pulse generating circuitry electrically coupled to the at least two electrodes of the sample holder;
- an user input device;
- and
- control circuitry configured to:
- receive instructions from the user input device;
- generate a set of pulse parameters based on the received instruction;
- and
- cause the pulse generating circuitry to provide a sequence of electrical pulses between the two electrodes based on the set of pulse parameters to transform a sample disposed in the sample holder into an activated product composition;
- wherein the received instructions comprise a set of growth factors released by one or more platelets, red blood cells, or white blood cells and a plurality of growth factor levels, wherein each growth factor level is associated with one growth factor of the set of growth factors.
7 more elements
A system for customizing an activated blood-derived cell treatment comprising:
- a sample holder configured to receive a sample comprising platelet rich plasma sample, a platelet suspension, or a whole blood sample;
- pulse generating circuitry configured to expose the sample disposed in the sample holder to an electrical pulse sequence;
- processing circuitry;
- an user input device;
- and
- a non-transient memory configured to store at least one processor-executable routine configured to cause the processor to:
- receive a selection for treating a patient, wherein the selection comprises a type of wound, a wound healing cascade process, or both;
- generate a customized growth factor profile based on the selected treatment by adjustably controlling an amount of one or more growth factors to be present in an activated product composition relative to an amount of one or more different growth factors to be present in the activated product composition;
- selecting one or more electric pulse parameters from a set of electric pulse parameters stored in the non-transient memory and a cuvette size from a set of cuvette sizes stored in the non-transient memory, wherein the selected cuvette size and the selected one or more electric pulse parameters corresponding to the customized growth factor profile;
- and
- expose the sample placed in the sample holder to one or more electric pulses generated based on the selected electric pulse parameters to generated an activated product composition having the customized growth factor profile.
8 more elements
Dependencies are inferred from the claim text.