Carboxyl cross-linked chondroitin hydrogels and their use for soft tissue applications
AssigneeGalderma S.A.
InventorsAnders KARLSSON, Hotan MOJARRADI
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Abstract
A hydrogel product is comprising a chondroitin, molecule selected from the group consisting of chondroitin and chondroitin sulfate as the swellable polymer, wherein the chondroitin molecule is cross-linked into a network via its carboxyl groups. The hydrogel product can be prepared by a process comprising the steps of (a) providing chondroitin molecules; (b) activating the carboxyl groups on the chondroitin molecules with a triazine-based coupling reagent to form an activated, cross-linked chondroitin; and (c) cross-linking the activated chondroitin molecules via their carboxyl groups using a cross-linking agent. The hydrogel product is useful for treatment of soft tissue disorders.
Claims19
A process of preparing a hydrogel product comprising a cross-linked network of chondroitin molecules, comprising the steps of:
- (a) providing chondroitin molecules selected from the group consisting of chondroitin and chondroitin sulfate;
- (b) activating the carboxyl groups on the chondroitin molecules with a triazine-based coupling reagent to form an activated, cross-linked chondroitin;
- (c) cross-linking the activated chondroitin molecules to each other via their carboxyl groups using a cross-linking agent.
A hydrogel product comprising a cross-linked network of chondroitin molecules selected from the group consisting of chondroitin and chondroitin sulfate as the swellable polymer, wherein the chondroitin molecules are cross-linked to each other via their carboxyl groups, essentially without any N-acylurea groups on the chondroitin molecules.
Dependencies are inferred from the claim text.