Novel anti-b7h3 binding compounds and uses thereof

An isolated antibody binding compound specific for the human B7H3 comprising heavy chain and light chain complementary determining regions (CDRs) defined by the following amino acid sequences:

• heavy chain CDR1:
• (SEQ ID NO:
• 1)
• N-Y-D-I-N;
• heavy chain CDR2:
• (SEQ ID NO:
• 2)
• W-I-F-P-G-D-G-S-T-Q-Y-N-X1-X2-F-K-G;
• heavy chain CDR3:
• (SEQ ID NO:
• 3)
• Q-T-T-X3-T-W-F-A-Y;
• light chain CDR1:
• (SEQ ID NO:
• 4)
• R-A-S-Q-X4-I-S-X5-X6-L-H;
• light chain CDR2:
• (SEQ ID NO:
• 5)
• X7-A-X8-Q-X9-X10-X11;
• light chain CDR3:
• (SEQ ID NO:
• 6)
• Q-N-G-H-S-F-P-L-T;
• wherein:
• X1 is E, G or P;
• X2 is K or T;
• X3 is G, S, M or N;
• X4 is S or I;
• X5 is E, P, V, H, T, K or D;
• X6 is Y or W;
• X7 is H, Y, N or E;
• X8 is S or N;
• X9 is S or L;
• X10 is I, W or L;
• X11 is S or R.