Synthetic foldable proteins generated from peptide segments of folding nuclei of reference proteins
AssigneeThe Florida State University Research Foundation, Inc.
InventorsMichael Blaber, Liam M. Longo
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Abstract
A method of making a synthetic foldable having a tertiary structure emulating the tertiary structure of a reference foldable protein is described. The method includes determining a folding nucleus peptide sequence associated with folding the reference foldable protein. The synthetic foldable protein is synthesized by including the determined folding nucleus peptide sequence and at least one repeat thereof in the peptide sequence of the synthetic foldable protein.
Claims13
A method of making a foldable protein that emulates the tertiary structure of a reference foldable protein using a folding nucleus peptide sequence associated with folding the reference foldable protein, the method comprising synthesizing a synthetic foldable protein having a tertiary structure emulating the tertiary structure of the reference foldable protein by including the folding nucleus peptide sequence of the reference foldable protein and at least one repeat thereof in the peptide sequence of the synthetic foldable protein.
A composition comprising a synthetic foldable protein having a tertiary structure emulating the tertiary structure of a reference foldable protein having a folding nucleus peptide sequence associated with folding the reference foldable protein, the synthetic foldable protein having a peptide sequence including the folding nucleus peptide sequence and at least one repeat thereof.
Dependencies are inferred from the claim text.