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AssigneesMonash University, La Trobe University, Peptides International, Inc., Baylor College of Medicine
InventorsRaymond S. NORTON, Shih Chieh CHANG, Michael W. PENNINGTON, Christine BEETON, Brian J. SMITH
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Novel analogues of the sea anemone Stichodactyla helianthus toxin ShK, and their use as, for example, therapeutic agents for treating autoimmune diseases are disclosed. The analogues comprise a ShK toxin polypeptide and an N-terminal extension comprising an amino acid sequence according to formula (I): wherein X−4 is D, E or other negatively-charged amino acid or derivative thereof, X−3 is E, I, L, S, V, W or a tryptophan derivative, X−2 is any amino acid, X−1 is any amino acid, a is absent or a first additional moiety, and b is absent or a second additional moiety. a-X−4X−3X−2X−1-b (SEQ ID NO: 3) (I)
An analogue of Stichodactyla helianthus toxin ShK comprising an ShK toxin polypeptide and an N-terminal extension comprising an amino acid sequence according to formula (I):
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Dependencies are inferred from the claim text.