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US 2017/0362283 A1Published application
Nisin-based compounds and use thereof in the treatment of bacterial infections
AssigneeUniversiteit Utrecht Holding B.V.
InventorsNathaniel Isaac MARTIN, Timo KOOPMANS, Thomas Melvin WOOD, Laurens Henri Johan KLEIJN
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Abstract
The invention relates to new antimicrobial compounds derived from nisin. In particular, the compounds are based on the unsubstituted nisin [1-12] structure, wherein said compounds have an antimicrobial activity exceeding the activity of the unsubstituted nisin [1-12] structure.
Claims15
An antimicrobial compound according to Formula (1),
- wherein:
- Z is selected from any one of the substituents NHR1, NR1R2, OR1 and SR1, and Y is selected from any one of the substituents NHR3, NR3R4, NHCR3R4, NHCOR3, NHCSR3, NHOR3 and NHC(NR3NHR4), wherein R1, R2, R3 and/or R4 is a substituted or non-substituted substituent selected from:
- alkyl, alkenyl, alkynyl, cycloalkyl, aryl, and polyaryl, wherein said substituent comprises at least 2, 4 or 6 carbon atoms and at most 30, 40 or 50 carbon atoms;
- A1 and A3 are independently D-Alanine or D-Aminobutyric acid;
- A2 and A4 are L-alanine;
- A1+A2 and A3+A4 independently form a (2S,6R)-lanthionine or (2S,3S,6R)-methyllanthionine linkage;
- and
- X1 to X8 are each independently selected from natural or non-natural amino acids.
5 more elements
Dependencies are inferred from the claim text.