Melampomagnolide b dimers

A compound comprising Formula (I) or a pharmaceutical acceptable salt thereof:

• wherein:
• Z is independently selected from the group consisting of CH2, O, C(O), and CH, wherein when Z is CH, Z is connected to Y via a double bond and Y is N;
• Y is independently selected from the group consisting of O, NR, N,
• heterocycle, hydrocarbyl and substituted hydrocarbyl,
• wherein R is selected from the group consisting of H, alkyl, hydrocarbyl and substituted hydrocarbyl and W is selected from the group consisting of O, S, NH, N-alkyl, heterocycle, alkyl, substituted alkyl, hydrocarbyl and substituted hydrocarbyl;
• X is selected from the group consisting of (CH2)n, C(O),
• —(CH2)n—W—C(O)—, —C(O)—W—C(O)—, —C(O)NH—W—NHC(O)—, —C(O)O—W—OC(O)—, carbocycle, heterocycle, alkyl, substituted alkyl, hydrocarbyl and substituted hydrocarbyl;
• wherein W is selected from the group consisting of O, S, NH, N-alkyl,
• heterocycle, alkyl, substituted alkyl, hydrocarbyl and substituted hydrocarbyl;
• and
• n is an integer from 0-10.