Substituted bridged urea analogs as sirtuin modulators

A compound of Formula (IV):

• wherein:
• R1 is —C(O)Ra or —C(O)—NRbRc;
• R2 is hydrogen, halogen, -straight or branched C1-C6 alkyl, -straight or branched-C1-C6 haloalkyl, or —C(O)—NRbRc;
• R3 is hydrogen, halogen, -hydroxy, -straight or branched C1-C6 alkyl, or -straight or branched-C1-C6 haloalkyl;
• each R5 and R6 independently is selected from hydrogen, -straight or branched C1-C6 alkyl, -straight or branched-C1-C6 haloalkyl, —C1-C6cycloalkyl, —(CH2)xC1-C6cycloalkyl, heterocyclyl, —N— heterocyclyl, aryl, heteroaryl, or —(CH2)xheteroaryl, —(CHRg)xheteroaryl;
• wherein:
• each R1, R2, R3, R5 and R6 as defined above optionally is further substituted with one or more substituents selected from hydrogen, halogen, —OH, —(CH2)xOH, —C≡N, —NRdRe, -straight or branched C1-C6 alkyl, -straight or branched-C1-C6 haloalkyl, -straight or branched C1-C6 alkoxy, -straight or branched C1-C6 haloalkoxy, —O-straight or branched-C1-C6 haloalkyl, —C1-C6 cycloalkyl, —(CH2)x-cycloalkyl, heterocyclyl, aryl, -heteroaryl, —(CH2)x-heteroaryl, —O—(CH2)xCH(OH)CH2(OH), or —C(O)ORf;
• each Ra, Rb, Rc, Rd, Re, Rf or Rg as define above independently is selected from hydrogen, -straight or branched C1-C6 alkyl, -straight or branched-C1-C6 haloalkyl, —C1-C6-cycloalkyl, —(CH2)xC1-C6-cycloalkyl, heterocyclyl, —N-heterocyclyl, aryl, heteroaryl, or —(CH2)xheteroaryl;
• wherein:
• each Ra, Rb, Rc Rd, Re, Rf or Rg as defined above optionally is further substituted with one or more substituents selected from hydrogen, halogen, —OH, —(CH2)xOH, —C≡N, —NRhRi, -straight or branched C1-C6 alkyl, -straight or branched-C1-C6 haloalkyl, -straight or branched C1-C6 alkoxy, -straight or branched-C1-C6 haloalkoxy, —C1-C6 cycloalkyl, —(CH2)x-cycloalkyl, heterocyclyl, -heterocyclyl, —O-heterocyclyl, aryl, -heteroaryl, —(CH2)x-heteroaryl, —O—(CH2)xCH(OH)CH2(OH), —(CH2)x—OH, or —C(O)ORj;
• wherein:
• each Rh, Ri and Rj independently is selected from hydrogen, -straight or branched C1-C6 alkyl or -straight or branched-C1-C6 haloalkyl;
• m is an integer from 1 to 3;
• n is an integer selected from 2 to 3;
• x is 0 or an integer from 1 to 6;
• or
• a pharmaceutically acceptable salt thereof.