Radioactive halogen-labeled pyrido [1,2-a] benzimidazole derivative compound
AssigneesKyoto University, Nihon Medi-Physics Co., Ltd.
InventorsMasahiro ONO, Hideo SAJI, Masafumi IHARA, Hiroki MATSUMOTO, Ikuya SEKI
Life of this patent
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Abstract
The present invention relates to a radioactive halogen-labeled pyrido[1,2-a]benzimidazole derivative compound represented by a specific general formula or a salt thereof, or a radiopharmaceutical comprising the same.
Claims9
A radioactive halogen-labeled compound represented by the following general formula (1) or a salt thereof:
- wherein one of R1 and R2 is a radioactive halogen atom, and the other is an alkyl group having 1 to 4 carbon atoms, an alkoxy group having 1 to 4 carbon atoms, an amino group, an alkylamino group having 1 to 4 carbon atoms, or a dialkylamino group having 2 to 4 carbon atoms.
A compound represented by the following general formula (2) or a salt thereof:
- wherein one of R3 and R4 is a halogen atom, a trialkylstannyl group, or a trialkylsilyl group, and the other is an alkyl group having 1 to 4 carbon atoms, an alkoxy group having 1 to 4 carbon atoms, an amino group, an alkylamino group having 1 to 4 carbon atoms, or a dialkylamino group having 2 to 4 carbon atoms.
A method for producing a radioactive halogen-labeled compound represented by the following general formula (1) or a salt thereof from a compound represented by the following general formula (2) or a salt thereof by radioactive halogenation reaction:
- wherein one of R3 and R4 is a halogen atom, a trialkylstannyl group, or a trialkylsilyl group, and the other is an alkyl group having 1 to 4 carbon atoms, an alkoxy group having 1 to 4 carbon atoms, an amino group, an alkylamino group having 1 to 4 carbon atoms, or a dialkylamino group having 2 to 4 carbon atoms, and
Dependencies are inferred from the claim text.