1,2,4-TRIAZOLO[4,3-a]PYRIDINE COMPOUNDS AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
AssigneeJanssen Pharmaceutica NV
InventorJosé Maria Cid-Núñez
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Abstract
The present invention relates to novel 1,2,4-triazolo[4,3-a]pyridine compounds as positive allosteric modulators (PAMs) of the metabotropic glutamate receptor subtype 2 (“mGluR2”). The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention or treatment of disorders in which mGluR2 subtype of metabotropic receptors is involved.
Claims15
A compound of Formula (I)
- or a stereochemically isomeric form thereof, wherein
- R1 is selected from C1-6alkyl, (C3-8cycloalkyl)C1-3alkyl, and (C1-3alkyloxy)C1-3alkyl;
- or a pharmaceutically acceptable salt thereof.
(canceled)
The method of claim 11 wherein the central nervous system disorder is epilepsy or convulsive disorders.
The method of claim 11 wherein the anxiety disorders is selected from the group consisting of agoraphobia, generalized anxiety disorder, panic disorder, social anxiety disorder (social phobia), and panic attack.
The method of claim 11 wherein the central nervous system disorder is panic disorder.
Dependencies are inferred from the claim text.