US 2017/0362218 A1Published application

Imidazo[4,5-c]pyridine derived ssao inhibitors

AssigneeProximagen Limited

InventorsMax Espensen, Lee Patient, Edward Savory

Life of this patent

Estimating the term…

Abstract

A compound as set out in claim 1, and the use of the same in therapy.

Claims15

Dependent claims

A compound selected from the group consisting of:

4-{5-[3-(5-Fluoropyridin-2-yl)-3H-imidazo[4,5-c]pyridin-2-yl]pyridin-2-yl}morpholine;
4-{5-[3-(2,4-Difluorophenyl)-3H-imidazo[4,5-c]pyridin-2-yl]-4-methylpyridin-2-yl}morpholine;
5-[3-(2,4-Difluorophenyl)-3H-imidazo[4,5-c]pyridin-2-yl]-N-(oxan-4-yl)pyrimidin-2-amine;
N,N-Diethyl-5-[3-(6-methylpyridin-3-yl)-3H-imidazo[4,5-c]pyridin-2-yl]pyrimidin-2-amine;
N,N-Diethyl-5-[3-(4-fluorophenyl)-3H-imidazo[4,5-c]pyridin-2-yl]pyrimidin-2-amine;
N,N-Diethyl-5-[3-(4-methylphenyl)-3H-imidazo[4,5-c]pyridin-2-yl]pyrimidin-2-amine;
N,N-Diethyl-5-[3-(5-methylpyridin-2-yl)-3H-imidazo[4,5-c]pyridin-2-yl]pyrimidin-2-amine;
4-{5-[3-(2-Fluoro-4-methylphenyl)-3H-imidazo[4,5-c]pyridin-2-yl]-4-methylpyridin-2-yl}morpholine;
4-{5-[3-(4-Chlorophenyl)-3H-imidazo[4,5-c]pyridin-2-yl]-4-methylpyridin-2-yl}morpholine;
5-[3-(4-Methylphenyl)-3H-imidazo[4,5-c]pyridin-2-yl]-N-(oxan-4-yl)pyridin-2-amine;
2-(4,4-Difluoropiperidin-1-yl)-5-[3-(4-methylphenyl)-3H-imidazo[4,5-c]pyridin-2-yl]pyridine;
4-{5-[3-(5-Chloropyridin-2-yl)-3H-imidazo[4,5-c]pyridin-2-yl]-4-methylpyridin-2-yl}morpholine;
4-{4-Methyl-5-[3-(5-methylpyridin-2-yl)-3H-imidazo[4,5-c]pyridin-2-yl]pyridin-2-yl}morpholine;
4-{5-[3-(5-Fluoropyridin-2-yl)-3H-imidazo[4,5-c]pyridin-2-yl]-4-methylpyridin-2-yl}morpholine;
5-[3-(4-Fluorophenyl)-3H-imidazo[4,5-c]pyridin-2-yl]-N-(oxan-4-yl)pyridin-2-amine;
4-{5-[3-(4-Fluorophenyl)-3H-imidazo[4,5-c]pyridin-2-yl]pyridin-2-yl}thiomorpholine;
N-Cyclopropyl-5-[3-(4-methylphenyl)-3H-imidazo[4,5-c]pyridin-2-yl]pyridin-2-amine;
5-[3-(6-Methylpyridin-3-yl)-3H-imidazo[4,5-c]pyridin-2-yl]-2-(pyrrolidin-1-yl)pyridine;
2-(4-Fluoropiperidin-1-yl)-5-[3-(6-methylpyridin-3-yl)-3H-imidazo[4,5-c]pyridin-2-yl]pyridine;
5-[3-(4-Fluorophenyl)-3H-imidazo [4,5-c]pyridin-2-yl]-N-[2-(morpholin-4-yl)ethyl]pyridin-2-amine;
5-[3-(4-Methylphenyl)-3H-imidazo [4,5-c]pyridin-2-yl]-N-[2-(morpholin-4-yl)ethyl]pyridin-2-amine;
N-Cyclopropyl-5-[3-(4-fluorophenyl)-3H-imidazo[4,5-c]pyridin-2-yl]pyridin-2-amine;
N-Cyclopropyl-5-[3-(6-methylpyridin-3-yl)-3H-imidazo[4,5-c]pyridin-2-yl]pyridin-2-amine;
5-[3-(4-Methylphenyl)-3H-imidazo [4,5-c]pyridin-2-yl]-N-(propan-2-yl)pyridin-2-amine;
5-[3-(6-Methylpyridin-3-yl)-3H-imidazo [4,5-c]pyridin-2-yl]-2-(pyrrolidin-1-yl)pyrimidine;
5-[3-(5-Methylpyridin-2-yl)-3H-imidazo [4,5-c]pyridin-2-yl]-2-(pyrrolidin-1-yl)pyrimidine;
5-[3-(5-Fluoropyridin-2-yl)-3H-imidazo [4,5-c]pyridin-2-yl]-2-(pyrrolidin-1-yl)pyrimidine;
4-{4-[3-(6-Methylpyridin-3-yl)-3H-imidazo [4,5-c]pyridin-2-yl]phenyl}morpholine;
5-[3-(4-Methylphenyl)-3H-imidazo [4,5-c]pyridin-2-yl]-2-(pyrrolidin-1-yl)pyrimidine;
4-{4-[3-(5-Methylpyridin-2-yl)-3H-imidazo [4,5-c]pyridin-2-yl]phenyl}morpholine;
2-Methyl-5-{2-[4-(pyrrolidin-1-yl)phenyl]-3H-imidazo [4,5-c]pyridin-3-yl}pyridine;
5-{2-[2-Fluoro-4-(pyrrolidin-1-yl)phenyl]-3H-imidazo [4,5-c]pyridin-3-yl}-2-methylpyridine;
4-{3-Fluoro-4-[3-(6-methylpyridin-3-yl)-3H-imidazo[4,5-c]pyridin-2-yl]phenyl}morpholine;
5-{2-[3-Fluoro-4-(pyrrolidin-1-yl)phenyl]-3H-imidazo [4,5-c]pyridin-3-yl}-2-methylpyridine;
N-{4-[3-(6-Methylpyridin-3-yl)-3H-imidazo [4,5-c]pyridin-2-yl]phenyl}oxan-4-amine;
5-Methyl-2-{2-[4-(pyrrolidin-1-yl)phenyl]-3H-imidazo [4,5-c]pyridin-3-yl}pyridine;
5-{2-[4-(4-Fluoropiperidin-1-yl)phenyl]-3H-imidazo [4,5-c]pyridin-3-yl}-2-methylpyridine;
2-Chloro-5-[3-(4-chlorophenyl)-3H-imidazo[4,5-c]pyridin-2-yl]pyridine;
2-Chloro-5-[3-(4-fluorophenyl)-3H-imidazo[4,5-c]pyridin-2-yl]pyridine;
and pharmaceutically acceptable salts thereof.

37 more elements

A pharmaceutical composition comprising

4-{5-[3-(5-Fluoropyridin-2-yl)-3H-imidazol[4,5-c]pyridin-2-yl]pyridin-2-yl}morpholine;
4-{5-[3-(2,4-Difluorophenyl)-3H-imidazol[4,5-c]pyridin-2-yl]-4-methylpyridin-2-yl}morpholine;
5-[3-(2,4-Difluorophenyl)-3H-imidazol[4,5-c]pyridin-2-yl]-N-(oxan-4-yl)pyrimidin-2-amine;
N,N-Diethyl-5-[3-(6-methylpyridin-3-yl)-3H-imidazol[4,5-c]pyridin-2-yl]pyrimidin-2-amine;
N,N-Diethyl-5-[3-(4-fluorophenyl)-3H-imidazol[4,5-c]pyridin-2-yl]pyrimidin-2-amine;
N,N-Diethyl-5-[3-(4-methylphenyl)-3H-imidazol[4,5-c]pyridin-2-yl]pyrimidin-2-amine;
N,N-Diethyl-5-[3-(5-methylpyridin-2-yl)-3H-imidazol[4,5-c]pyridin-2-yl]pyrimidin-2-amine;
4-{5-[3-(2-Fluoro-4-methylphenyl)-3H-imidazol[4,5-c]pyridin-2-yl]-4-methylpyridin-2-yl}morpholine;
4-{5-[3-(4-Chlorophenyl)-3H-imidazol[4,5-c]pyridin-2-yl]-4-methylpyridin-2-yl}morpholine;
5-[3-(4-Methylphenyl)-3H-imidazol[4,5-c]pyridin-2-yl]-N-(oxan-4-yl)pyridin-2-amine;
2-(4,4-Difluoropiperidin-1-yl)-5-[3-(4-methylphenyl)-3H-imidazol[4,5-c]pyridin-2-yl]pyridine;
4-{5-[3-(5-Chloropyridin-2-yl)-3H-imidazol[4,5-c]pyridin-2-yl]-4-methylpyridin-2-yl}morpholine;
4-{4-Methyl-5-[3-(5-methylpyridin-2-yl)-3H-imidazol[4,5-c]pyridin-2-yl]pyridin-2-yl}morpholine;
4-{5-[3-(5-Fluoropyridin-2-yl)-3H-imidazol[4,5-c]pyridin-2-yl]-4-methylpyridin-2-yl}morpholine;
5-[3-(4-Fluorophenyl)-3H-imidazol[4,5-c]pyridin-2-yl]-N-(oxan-4-yl)pyridin-2-amine;
4-{5-[3-(4-Fluorophenyl)-3H-imidazol[4,5-c]pyridin-2-yl]pyridin-2-yl}thiomorpholine;
N-Cyclopropyl-5-[3-(4-methylphenyl)-3H-imidazol[4,5-c]pyridin-2-yl]pyridin-2-amine;
5-[3-(6-Methylpyridin-3-yl)-3H-imidazol[4,5-c]pyridin-2-yl]-2-(pyrrolidin-1-yl)pyridine;
2-(4-Fluoropiperidin-1-yl)-5-[3-(6-methylpyridin-3-yl)-3H-imidazol[4,5-c]pyridin-2-yl]pyridine;
5-[3-(4-Fluorophenyl)-3H-imidazol[4,5-c]pyridin-2-yl]-N-[2-(morpholin-4-yl)ethyl]pyridin-2-amine;
5-[3-(4-Methylphenyl)-3H-imidazol[4,5-c]pyridin-2-yl]-N-[2-(morpholin-4-yl)ethyl]pyridin-2-amine;
N-Cyclopropyl-5-[3-(4-fluorophenyl)-3H-imidazol[4,5-c]pyridin-2-yl]pyridin-2-amine;
N-Cyclopropyl-5-[3-(6-methylpyridin-3-yl)-3H-imidazol[4,5-c]pyridin-2-yl]pyridin-2-amine;
5-[3-(4-Methylphenyl)-3H-imidazol[4,5-c]pyridin-2-yl]-N-(propan-2-yl)pyridin-2-amine;
5-[3-(6-Methylpyridin-3-yl)-3H-imidazol[4,5-c]pyridin-2-yl]-2-(pyrrolidin-1-yl)pyrimidine;
5-[3-(5-Methylpyridin-2-yl)-3H-imidazol[4,5-c]pyridin-2-yl]-2-(pyrrolidin-1-yl)pyrimidine;
5-[3-(5-Fluoropyridin-2-yl)-3H-imidazol[4,5-c]pyridin-2-yl]-2-(pyrrolidin-1-yl)pyrimidine;
4-{4-[3-(6-Methylpyridin-3-yl)-3H-imidazol[4,5-c]pyridin-2-yl]phenyl}morpholine;
5-[3-(4-Methylphenyl)-3H-imidazol[4,5-c]pyridin-2-yl]-2-(pyrrolidin-1-yl)pyrimidine;
4-{4-[3-(5-Methylpyridin-2-yl)-3H-imidazol[4,5-c]pyridin-2-yl]phenyl}morpholine;
2-Methyl-5-{2-[4-(pyrrolidin-1-yl)phenyl]-3H-imidazo[4,5-c]pyridin-3-yl}pyridine;
5-{2-[2-Fluoro-4-(pyrrolidin-1-yl)phenyl]-3H-imidazo[4,5-c]pyridin-3-yl}-2-methylpyridine;
4-{3-Fluoro-4-[3-(6-methylpyridin-3-yl)-3H-imidazo[4,5-c]pyridin-2-yl]phenyl}morpholine;
5-{2-[3-Fluoro-4-(pyrrolidin-1-yl)phenyl]-3H-imidazo[4,5-c]pyridin-3-yl}-2-methylpyridine;
N-{4-[3-(6-Methylpyridin-3-yl)-3H-imidazo[4,5-c]pyridin-2-yl]phenyl}oxan-4-amine;
5-Methyl-2-{2-[4-(pyrrolidin-1-yl)phenyl]-3H-imidazo[4,5-c]pyridin-3-yl}pyridine;
5-{2-[4-(4-Fluoropiperidin-1-yl)phenyl]-3H-imidazo[4,5-c]pyridin-3-yl}-2-methylpyridine;
2-Chloro-5-[3-(4-chlorophenyl)-3H-imidazo[4,5-c]pyridin-2-yl]pyridine;
2-Chloro-5-[3-(4-fluorophenyl)-3H-imidazo[4,5-c]pyridin-2-yl]pyridine;
or a pharmaceutically acceptable salt thereof,
together with one or more pharmaceutically acceptable carriers and/or excipients.

38 more elements

A method for the treatment of inflammation, an inflammatory disease, an immune or an autoimmune disorder, or inhibition of tumour growth, which comprises administering to a subject suffering such disease an effective amount of

4-{5-[3-(5-Fluoropyridin-2-yl)-3H-imidazo[4,5-c]pyridin-2-yl]pyridin-2-yl}morpholine;
4-{5-[3-(2,4-Difluorophenyl)-3H-imidazo[4,5-c]pyridin-2-yl]-4-methylpyridin-2-yl}morpholine;
5-[3-(2,4-Difluorophenyl)-3H-imidazo[4,5-c]pyridin-2-yl]-N-(oxan-4-yl)pyrimidin-2-amine;
N,N-Diethyl-5-[3-(6-methylpyridin-3-yl)-3H-imidazo[4,5-c]pyridin-2-yl]pyrimidin-2-amine;
N,N-Diethyl-5-[3-(4-fluorophenyl)-3H-imidazo[4,5-c]pyridin-2-yl]pyrimidin-2-amine;
N,N-Diethyl-5-[3-(4-methylphenyl)-3H-imidazo[4,5-c]pyridin-2-yl]pyrimidin-2-amine;
N,N-Diethyl-5-[3-(5-methylpyridin-2-yl)-3H-imidazo[4,5-c]pyridin-2-yl]pyrimidin-2-amine;
4-{5-[3-(2-Fluoro-4-methylphenyl)-3H-imidazo[4,5-c]pyridin-2-yl]-4-methylpyridin-2-yl}morpholine;
4-{5-[3-(4-Chlorophenyl)-3H-imidazo[4,5-c]pyridin-2-yl]-4-methylpyridin-2-yl}morpholine;
5-[3-(4-Methylphenyl)-3H-imidazo[4,5-c]pyridin-2-yl]-N-(oxan-4-yl)pyridin-2-amine;
2-(4,4-Difluoropiperidin-1-yl)-5-[3-(4-methylphenyl)-3H-imidazo[4,5-c]pyridin-2-yl]pyridine;
4-{5-[3-(5-Chloropyridin-2-yl)-3H-imidazo[4,5-c]pyridin-2-yl]-4-methylpyridin-2-yl}morpholine;
4-{4-Methyl-5-[3-(5-methylpyridin-2-yl)-3H-imidazol[4,5-c]pyridin-2-yl]pyridin-2-yl}morpholine;
4-{5-[3-(5-Fluoropyridin-2-yl)-3H-imidazol[4,5-c]pyridin-2-yl]-4-methylpyridin-2-yl}morpholine;
5-[3-(4-Fluorophenyl)-3H-imidazol[4,5-c]pyridin-2-yl]-N-(oxan-4-yl)pyridin-2-amine;
4-{5-[3-(4-Fluorophenyl)-3H-imidazo[4,5-c]pyridin-2-yl]pyridin-2-yl}thiomorpholine;
N-Cyclopropyl-5-[3-(4-methylphenyl)-3H-imidazol[4,5-c]pyridin-2-yl]pyridin-2-amine;
5-[3-(6-Methylpyridin-3-yl)-3H-imidazol[4,5-c]pyridin-2-yl]-2-(pyrrolidin-1-yl)pyridine;
2-(4-Fluoropiperidin-1-yl)-5-[3-(6-methylpyridin-3-yl)-3H-imidazol[4,5-c]pyridin-2-yl]pyridine;
5-[3-(4-Fluorophenyl)-3H-imidazol[4,5-c]pyridin-2-yl]-N-[2-(morpholin-4-yl)ethyl]pyridin-2-amine;
5-[3-(4-Methylphenyl)-3H-imidazol[4,5-c]pyridin-2-yl]-N-[2-(morpholin-4-yl)ethyl]pyridin-2-amine;
N-Cyclopropyl-5-[3-(4-fluorophenyl)-3H-imidazol[4,5-c]pyridin-2-yl]pyridin-2-amine;
N-Cyclopropyl-5-[3-(6-methylpyridin-3-yl)-3H-imidazol[4,5-c]pyridin-2-yl]pyridin-2-amine;
5-[3-(4-Methylphenyl)-3H-imidazol[4,5-c]pyridin-2-yl]-N-(propan-2-yl)pyridin-2-amine;
5-[3-(6-Methylpyridin-3-yl)-3H-imidazol[4,5-c]pyridin-2-yl]-2-(pyrrolidin-1-yl)pyrimidine;
5-[3-(5-Methylpyridin-2-yl)-3H-imidazol[4,5-c]pyridin-2-yl]-2-(pyrrolidin-1-yl)pyrimidine;
5-[3-(5-Fluoropyridin-2-yl)-3H-imidazol[4,5-c]pyridin-2-yl]-2-(pyrrolidin-1-yl)pyrimidine;
4-{4-[3-(6-Methylpyridin-3-yl)-3H-imidazol[4,5-c]pyridin-2-yl]phenyl}morpholine;
5-[3-(4-Methylphenyl)-3H-imidazol[4,5-c]pyridin-2-yl]-2-(pyrrolidin-1-yl)pyrimidine;
4-{4-[3-(5-Methylpyridin-2-yl)-3H-imidazol[4,5-c]pyridin-2-yl]phenyl}morpholine;
2-Methyl-5-{2-[4-(pyrrolidin-1-yl)phenyl]-3H-imidazol[4,5-c]pyridin-3-yl}pyridine;
5-{2-[2-Fluoro-4-(pyrrolidin-1-yl)phenyl]-3H-imidazol[4,5-c]pyridin-3-yl}-2-methylpyridine;
4-{3-Fluoro-4-[3-(6-methylpyridin-3-yl)-3H-imidazol[4,5-c]pyridin-2-yl]phenyl}morpholine;
5-{2-[3-Fluoro-4-(pyrrolidin-1-yl)phenyl]-3H-imidazol[4,5-c]pyridin-3-yl}-2-methylpyridine;
N-{4-[3-(6-Methylpyridin-3-yl)-3H-imidazol[4,5-c]pyridin-2-yl]phenyl}oxan-4-amine;
5-Methyl-2-{2-[4-(pyrrolidin-1-yl)phenyl]-3H-imidazol[4,5-c]pyridin-3-yl}pyridine;
5-{2-[4-(4-Fluoropiperidin-1-yl)phenyl]-3H-imidazol[4,5-c]pyridin-3-yl}-2-methylpyridine;
2-Chloro-5-[3-(4-chlorophenyl)-3H-imidazol[4,5-c]pyridin-2-yl]pyridine;
2-Chloro-5-[3-(4-fluorophenyl)-3H-imidazo[4,5-c]pyridin-2-yl]pyridine;
or a pharmaceutically acceptable salt thereof.

37 more elements

Dependencies are inferred from the claim text.

Facts

Application: 15/506,885Filed 17 Sep 2015
Priority: GB 1416446.117 Sep 2014
Published: 21 Dec 2017
Term ends: Not estimatedThe source records don’t support an estimate.

Classification27 codes

C07D 471/04
In which the condensed system contains two hetero rings: ortho-condensed systems
A61P 1/04
Drugs for disorders of the alimentary tract or the digestive system: for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of…
A61P 1/16
Drugs for disorders of the alimentary tract or the digestive system: for liver or gallbladder disorders, e.g. hepatoprotective agents,…
A61P 3/10
For glucose homeostasis: for hyperglycaemia, e.g. antidiabetics

Family

US 10,065,954 B2Related patent
US 2017/0362218 A1This patent

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A compound selected from the group consisting of:

4-{5-[3-(5-Fluoropyridin-2-yl)-3H-imidazo[4,5-c]pyridin-2-yl]pyridin-2-yl}morpholine;
4-{5-[3-(2,4-Difluorophenyl)-3H-imidazo[4,5-c]pyridin-2-yl]-4-methylpyridin-2-yl}morpholine;
5-[3-(2,4-Difluorophenyl)-3H-imidazo[4,5-c]pyridin-2-yl]-N-(oxan-4-yl)pyrimidin-2-amine;
N,N-Diethyl-5-[3-(6-methylpyridin-3-yl)-3H-imidazo[4,5-c]pyridin-2-yl]pyrimidin-2-amine;
N,N-Diethyl-5-[3-(4-fluorophenyl)-3H-imidazo[4,5-c]pyridin-2-yl]pyrimidin-2-amine;
N,N-Diethyl-5-[3-(4-methylphenyl)-3H-imidazo[4,5-c]pyridin-2-yl]pyrimidin-2-amine;
N,N-Diethyl-5-[3-(5-methylpyridin-2-yl)-3H-imidazo[4,5-c]pyridin-2-yl]pyrimidin-2-amine;
4-{5-[3-(2-Fluoro-4-methylphenyl)-3H-imidazo[4,5-c]pyridin-2-yl]-4-methylpyridin-2-yl}morpholine;
4-{5-[3-(4-Chlorophenyl)-3H-imidazo[4,5-c]pyridin-2-yl]-4-methylpyridin-2-yl}morpholine;
5-[3-(4-Methylphenyl)-3H-imidazo[4,5-c]pyridin-2-yl]-N-(oxan-4-yl)pyridin-2-amine;
2-(4,4-Difluoropiperidin-1-yl)-5-[3-(4-methylphenyl)-3H-imidazo[4,5-c]pyridin-2-yl]pyridine;
4-{5-[3-(5-Chloropyridin-2-yl)-3H-imidazo[4,5-c]pyridin-2-yl]-4-methylpyridin-2-yl}morpholine;
4-{4-Methyl-5-[3-(5-methylpyridin-2-yl)-3H-imidazo[4,5-c]pyridin-2-yl]pyridin-2-yl}morpholine;
4-{5-[3-(5-Fluoropyridin-2-yl)-3H-imidazo[4,5-c]pyridin-2-yl]-4-methylpyridin-2-yl}morpholine;
5-[3-(4-Fluorophenyl)-3H-imidazo[4,5-c]pyridin-2-yl]-N-(oxan-4-yl)pyridin-2-amine;
4-{5-[3-(4-Fluorophenyl)-3H-imidazo[4,5-c]pyridin-2-yl]pyridin-2-yl}thiomorpholine;
N-Cyclopropyl-5-[3-(4-methylphenyl)-3H-imidazo[4,5-c]pyridin-2-yl]pyridin-2-amine;
5-[3-(6-Methylpyridin-3-yl)-3H-imidazo[4,5-c]pyridin-2-yl]-2-(pyrrolidin-1-yl)pyridine;
2-(4-Fluoropiperidin-1-yl)-5-[3-(6-methylpyridin-3-yl)-3H-imidazo[4,5-c]pyridin-2-yl]pyridine;
5-[3-(4-Fluorophenyl)-3H-imidazo [4,5-c]pyridin-2-yl]-N-[2-(morpholin-4-yl)ethyl]pyridin-2-amine;
5-[3-(4-Methylphenyl)-3H-imidazo [4,5-c]pyridin-2-yl]-N-[2-(morpholin-4-yl)ethyl]pyridin-2-amine;
N-Cyclopropyl-5-[3-(4-fluorophenyl)-3H-imidazo[4,5-c]pyridin-2-yl]pyridin-2-amine;
N-Cyclopropyl-5-[3-(6-methylpyridin-3-yl)-3H-imidazo[4,5-c]pyridin-2-yl]pyridin-2-amine;
5-[3-(4-Methylphenyl)-3H-imidazo [4,5-c]pyridin-2-yl]-N-(propan-2-yl)pyridin-2-amine;
5-[3-(6-Methylpyridin-3-yl)-3H-imidazo [4,5-c]pyridin-2-yl]-2-(pyrrolidin-1-yl)pyrimidine;
5-[3-(5-Methylpyridin-2-yl)-3H-imidazo [4,5-c]pyridin-2-yl]-2-(pyrrolidin-1-yl)pyrimidine;
5-[3-(5-Fluoropyridin-2-yl)-3H-imidazo [4,5-c]pyridin-2-yl]-2-(pyrrolidin-1-yl)pyrimidine;
4-{4-[3-(6-Methylpyridin-3-yl)-3H-imidazo [4,5-c]pyridin-2-yl]phenyl}morpholine;
5-[3-(4-Methylphenyl)-3H-imidazo [4,5-c]pyridin-2-yl]-2-(pyrrolidin-1-yl)pyrimidine;
4-{4-[3-(5-Methylpyridin-2-yl)-3H-imidazo [4,5-c]pyridin-2-yl]phenyl}morpholine;
2-Methyl-5-{2-[4-(pyrrolidin-1-yl)phenyl]-3H-imidazo [4,5-c]pyridin-3-yl}pyridine;
5-{2-[2-Fluoro-4-(pyrrolidin-1-yl)phenyl]-3H-imidazo [4,5-c]pyridin-3-yl}-2-methylpyridine;
4-{3-Fluoro-4-[3-(6-methylpyridin-3-yl)-3H-imidazo[4,5-c]pyridin-2-yl]phenyl}morpholine;
5-{2-[3-Fluoro-4-(pyrrolidin-1-yl)phenyl]-3H-imidazo [4,5-c]pyridin-3-yl}-2-methylpyridine;
N-{4-[3-(6-Methylpyridin-3-yl)-3H-imidazo [4,5-c]pyridin-2-yl]phenyl}oxan-4-amine;
5-Methyl-2-{2-[4-(pyrrolidin-1-yl)phenyl]-3H-imidazo [4,5-c]pyridin-3-yl}pyridine;
5-{2-[4-(4-Fluoropiperidin-1-yl)phenyl]-3H-imidazo [4,5-c]pyridin-3-yl}-2-methylpyridine;
2-Chloro-5-[3-(4-chlorophenyl)-3H-imidazo[4,5-c]pyridin-2-yl]pyridine;
2-Chloro-5-[3-(4-fluorophenyl)-3H-imidazo[4,5-c]pyridin-2-yl]pyridine;
and pharmaceutically acceptable salts thereof.

37 more elements

Facts

Application

15/506,885Filed 17 Sep 2015

Priority

GB 1416446.117 Sep 2014

Published

21 Dec 2017

Term ends

Not estimatedThe source records don’t support an estimate.

Classification27 codes

C07D 471/04
In which the condensed system contains two hetero rings: ortho-condensed systems
A61P 1/04
Drugs for disorders of the alimentary tract or the digestive system: for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of…
A61P 1/16
Drugs for disorders of the alimentary tract or the digestive system: for liver or gallbladder disorders, e.g. hepatoprotective agents,…
A61P 3/10
For glucose homeostasis: for hyperglycaemia, e.g. antidiabetics