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US 2017/0362212 A1Published application
Process for preparation of luliconazole
AssigneeGlenmark Pharmaceuticals S.A.
InventorsShekhar Bhaskar BHIRUD, Kumar Hari BHUSHAN, Sunil Sudhakar ZHOPE, Shailesh Govind GHADIGAONKAR, Fardeep SINGH, Shekhar Ashok DESHMUKH, Prem CHAND
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Abstract
A process for the preparation of luliconazole and salts thereof is disclosed.
Claims23
A process for the purification of luliconazole, a compound of formula I, comprising the steps of
- (i) contacting a mixture comprising luliconazole and stereoisomer(s) thereof in a solvent with an acid to provide a reaction mixture comprising an acid addition salt of luliconazole and an optionally acid addition salt of stereoisomer(s) of luliconazole;
- (ii) separating the acid addition salt of luliconazole from the reaction mixture;
- and
- (iii) basifying the separated acid addition salt of luliconazole to form luliconazole.
1 more element
(canceled)
(canceled)
Crystalline luliconazole hydrochloride, a compound of formula IV,
- characterized by X-ray diffraction (XRD) spectrum having peak reflections at about 4.0, 8.0, 11.9, 15.9 and 17.9±0.2 degrees 2 theta.
(canceled)
-21. (canceled)
A process for the purification of luliconazole, a compound of formula I,
- the process comprising:
- (i) contacting a mixture comprising an acid addition salt of luliconazole and stereoisomer(s) thereof in a solvent with hydrochloric acid to provide a reaction mixture comprising luliconazole hydrochloride and optionally any stereoisomer(s) of luliconazole;
- (ii) separating the luliconazole hydrochloride from the reaction mixture of step (ii);
- and
- (iii) basifying the separated luliconazole hydrochloride to form luliconazole.
2 more elements
Dependencies are inferred from the claim text.