Compounds, compositions, and methods

A compound of formula I:

• or a pharmaceutically acceptable salt, deuterated analog, prodrug, stereoisomer, or a mixture of stereoisomers thereof, wherein:
• R1 is optionally substituted cycloalkyl or, when R5 is —CR5aR6R7 where R5a is optionally substituted triazol-2-yl, R1 is optionally substituted cycloalkyl or C1-6 alkyl optionally substituted with halo;
• R2 is halo, cyano, optionally substituted C1-6 alkyl, optionally substituted C1-6 alkenyl, optionally substituted C1-6 alkynyl, optionally substituted cycloalkyl, optionally substituted C1-6 alkoxy, optionally substituted cycloalkoxy, optionally substituted C1-6 alkylthio, optionally substituted C1-6 alkylsulfonyl, —C(O)R10, or —C(O)N(R11)(R12);
• R3 is optionally substituted C1-6 alkoxy, optionally substituted cycloalkyl, optionally substituted cycloalkoxy, optionally substituted C1-6 alkylthio, optionally substituted C1-6 alkylsulfonyl, or
• —N(R11)(R12);
• R4 is hydrogen or halo;
• R5 is hydrogen, halo, cyano, optionally substituted C1-6 alkyl, optionally substituted C1-6 alkenyl, optionally substituted C1-6 alkynyl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted heteroaryl, optionally substituted C1-6 alkylthio, optionally substituted C1-6 alkyl sulfonyl, —C(O)R10, or —C(O)N(R11)(R12);
• each R10 is independently optionally substituted C1-6 alkyl or optionally substituted C1-6 alkoxy;
• and
• R11 and R12 are each independently hydrogen, optionally substituted C1-6 alkyl, or optionally substituted cycloalkyl.