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US 2017/0362192 A1Published application
Process for preparing ataluren and its intermediates
AssigneeScinoPharm Taiwan, Ltd.
InventorsTsung-Yu HSIAO, Yu-Hui HUANG, Wei-Yu CHEN
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Abstract
The present invention provides processes for the preparation of ataluren. Intermediates for preparing ataluren are also provided.
Claims27
A process for the preparation of ataluren
- the process comprising:
- a) contacting a compound of formula I
- with hydroxylamine to provide a compound of formula II
- and
- b) converting e compound of formula H to provide ataluren;
- wherein:
- R1 and R2 are independently selected from the group consisting of C1-C6 alkyl and C1-C6 acyl;
- or
- R1 and R2 are taken together to form an optionally substituted 5-7 member cyclic acetal.
6 more elements
A compound of formula II:
- wherein
- R1 and R2 are independently selected from the group consisting of C1-C6 alkyl and C1-C6 acyl;
- or
- R1 and R2 are taken together to form an optionally substituted 5-7 member cyclic acetal.
1 more element
25-31. (canceled)
Dependencies are inferred from the claim text.