Procedure for the preparation of 4-phenyl butyrate and uses thereof
AssigneeHorizon Therapeutics, LLC
InventorsHuai-Chueh CHANG, Steven S. PFEIFFER, Vasilios H. ISKOS, Maki URAGAMI, Steven WEISSMAN, Andrew THOMPSON
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Abstract
Provided is a process for preparing 4-phenyl-1-butyric acid, comprising: reacting 4-phenyl-1-butanol with sodium chlorite, a nitroxyl radical catalyst and sodium hypochlorite in an organic solvent and a phosphate buffer; and quenching the reaction with sodium sulfite to produce 4-phenyl-1-butyric. Also provided is 4-phenyl-1-butyric acid prepared by such a process.
Claims11
1-29. (canceled)
A composition comprising 4-phenyl-1-butyric acid, wherein the composition comprises less than 0.002% 3-benzoyl propionic acid w/w.
A composition comprising glycerol triphenylbutyrate, wherein the composition comprises less than 0.002% 3-benzoyl propionic acid w/w.
Dependencies are inferred from the claim text.