Gas Exchange Composite Membranes and Methods of Use Thereof
AssigneeThe Regents of the University of California
InventorsShuvo Roy, Torin Yeager, Emily Abada, Ajay S. Dharia
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Abstract
Provided herein is a gas exchange composite membrane and methods of making the same. The gas exchange composite membrane may find use in a method of exchanging gas with blood in a subject in need of blood oxygenation support, which method is also disclosed. Also provided herein are systems and kits that find use in performing the methods of exchanging gas with blood.
Claims92
A gas exchange composite membrane comprising:
- i) a non-porous, gas-permeable, polymeric membrane defining a first surface and a second surface opposite the first surface;
- and
- ii) a non-compliant, microporous membrane defining a third surface and a fourth surface opposite the third surface, wherein
- the microporous membrane comprises one or more gas diffusion windows, each comprising a network of struts defining walls of a plurality of micropores, each micropore extending from the third surface to the fourth surface;
- and
- the third surface is attached to the second surface,
- wherein the first surface of the polymeric membrane provides an antithrombotic surface for gas exchange over the one or more gas diffusion windows, between blood flowing along the first surface and a gas at the second surface.
A method of making a gas exchange composite membrane, comprising:
- a) forming a non-compliant, microporous membrane defining a first surface;
- b) forming a multilayered membrane-supporting structure comprising a plurality of layers superposed among each other, wherein the multilayered membrane-supporting structure defines a second surface comprising a superficial layer of the plurality of superposed layers, and wherein the superficial layer comprises a non-porous, gas-permeable, polymeric membrane detachably disposed over an underlying layer;
- c) bonding the first surface to the second surface;
- and
- d) detaching the underlying layer from the non-porous, gas-permeable, polymeric membrane, thereby exposing a third surface of the non-porous, gas-permeable, polymeric membrane,
- wherein the third surface provides an antithrombotic surface for gas exchange across the composite membrane, between blood flowing along the third surface and a gas at a fourth surface of the non-compliant, microporous membrane opposite the first surface.
A method of exchanging gas with blood comprising a first dissolved gaseous compound, the method comprising:
- (A) pumping blood from a circulatory system of a subject to an extracorporeal blood circuit to generate a circulating flow of the blood, the extracorporeal blood circuit comprising one or more non-circuitous blood channels of one or more blood oxygenating devices, each blood channel defining a first end and a second end opposite the first end, wherein each of the blood oxygenating devices comprises:
- a gas channel configured to pass a flow of gas, wherein the gas comprises a second gaseous compound;
- one or more gas exchange composite membranes configured to exchange gaseous compounds between the blood and the gas across a planar surface separating the blood channel and the gas channel;
- and
- (B) flowing the gas through the gas channel,
- thereby exchanging gaseous compounds between the circulating flow of the blood and the gas.
Dependencies are inferred from the claim text.