Medical device coating with a biocompatible layer

The device of any of the preceding claims, wherein the hydrogel layer substantially surrounds the outer surface of the device.

The device of any of the preceding claims, wherein the hydrogel layer or the hydrogel layer and device are substantially optically clear.

The device of any of the preceding claims, wherein the hydrogel layer is adapted to allow optical transmission through the hydrogel layer to the device.

The device of any of the preceding claims, wherein the hydrogel layer is adapted to attenuate x-ray transmission.

The device of any of the preceding claims, wherein the hydrogel layer is adapted to enable diffusion of biologic molecules, glucose, solutes, polymers, drugs.

The device of any of the preceding claims, wherein the hydrogel layer comprises a thickness between about 5 nm to about 30 nm.

The device of any of the preceding claims, wherein the hydrogel layer comprises a thickness below about 100 nm.

The device of any of the proceeding claims, wherein the hydrogel layer comprises a thickness less than about 50 nm.

The device of any of the proceeding claims, wherein the hydrogel layer comprises a thickness less than about 1 micron.

The device of any of the preceding claims, wherein the hydrogel layer comprises a maximum thickness of about 10 microns.

The device of any of the preceding claims, wherein a first portion of the hydrogel layer comprises a first thickness different from a second thickness of a second portion of the hydrogel layer.

The device of any of the preceding claims, wherein each of the first and second hydrophilic polymer species is a branched species having a branch count between two to twelve branch arms.

The device of any of the preceding claims, wherein the first hydrophilic polymer species comprises a reactive electron pair accepting group and the second hydrophilic polymer species comprises a reactive nucleophilic group, the reactive electron pair accepting group and the reactive nucleophilic group adapted to react to thereby form cross-links between the first hydrophilic polymer species to the second hydrophilic polymer species.

The device of any of the preceding claims, wherein the hydrogel layer has a lower coefficient of friction than an underlying device surface.

The device of any of the preceding claims, wherein the hydrogel layer has a relative protein resistance compared to an underlying device surface.

The device of any of the preceding claims, wherein the hydrogel layer comprises between about 80% to about 98% water by weight.

A medical device comprising:

• an outer surface covered by an outer biocompatible polymer layer, wherein the biocompatible polymer layer comprises a first polyethylene glycol (PEG) macromer subpopulation having an electron pair accepting moiety and a second macromer subpopulation comprising polyacrylamide having a first nucleophilic reactive moiety, wherein the first and second macromer subpopulations are cross-linked.

A method of making a medical device with a hydrophilic polymer layer comprising:

• reacting an outer surface of the medical device with a first polymer species of a hydrophilic polymer solution, wherein the first polymer species comprises a moiety at a first portion that forms a covalent attachment to the outer surface of the device;
• and
• reacting the first polymer species of the hydrophilic polymer solution with a second polymer species of the hydrophilic polymer solution, the second polymer species comprising a moiety that forms a covalent bond to a second portion of the first polymer species in a second covalent reaction thereby forming a hydrogel coating comprising the first polymer species and the second polymer species at least partially cross-linked.