Coated endovascular prostheses for aneurism treatment
AssigneeMedtronic Vascular, Inc.
InventorsJeffery Argentine, Matt Petruska, Keith Perkins, Samuel Robaina, Darren Galligan, Rajesh Radhakrishnan
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Abstract
The present technology relates generally to endovascular prostheses. More particularly, the disclosure relates to endovascular prostheses having an outer surface of a graft material thereof associated with a hydrogel composition, which may swell upon implantation within a blood vessel, thereby mediating various complications associated with endovascular procedures. The hydrogel compositions can also include various stabilizing polymers and active agents to further aid their use in the body.
Claims29
An endovascular prosthesis having a compressed configuration for delivery within a vasculature and a radially-expanded configuration for deployment within a target blood vessel of a patient, the endovascular prosthesis comprising:
- an anchor stent for engaging an inner wall of the target blood vessel when the prosthesis is in the radially-expanded configuration;
- a tubular body formed from a graft material defining a central lumen from a first end to a second end thereof, wherein the anchor stent is attached to the first end of the tubular body, the tubular body having an inner surface and an outer surface;
- a body stent attached to the outer surface of the tubular body for maintaining the tubular body in the radially-expanded configuration;
- and
- a hydrogel composition associated with about 20% to about 100% of the outer surface of the tubular body, the hydrogel composition comprising a hydrogel polymer and one or more of a stabilizing polymer, a biologically active agent and a bioabsorbable polymer, wherein the hydrogel composition is in a non-expanded state and capable of expanding to an expanded state following introduction into the target blood vessel of the patient.
An endovascular prosthesis comprising:
- a tubular body formed from a graft material, the tubular body having an inner surface and an outer surface;
- and
- a hydrogel composition associated with at least a portion of the outer surface of the tubular body,
- wherein the hydrogel composition in a non-expanded state and capable of expanding to an expanded state following introduction into a target blood vessel of a patient.
A method of delivering a hydrogel-associated endovascular prosthesis to a target blood vessel of a patient, the method comprising:
- providing a hydrogel-associated endovascular prosthesis having a compressed configuration for delivery within a vasculature and a radially-expanded configuration for deployment within the target blood vessel, the prosthesis comprising:
- an anchor stent for engaging an inner wall of the target blood vessel when the prosthesis is in the radially-expanded configuration;
- a tubular body formed from a graft material defining a central lumen from a first end to a second end thereof, wherein the anchor stent is attached to the first end of the tubular body, the tubular body having an inner surface and an outer surface;
- a body stent attached to the outer surface of the tubular body for maintaining the tubular body in the radially-expanded configuration;
- and
- a hydrogel composition associated with about 20% to about 100% of the outer surface of the tubular body, the hydrogel composition comprising a hydrogel polymer and one or more of a stabilizing polymer, a biologically active agent and a bioabsorbable polymer, wherein the hydrogel composition in a non-expanded state and capable of expanding to an expanded state following introduction into the target blood vessel of the patient;
- introducing the hydrogel-associated endovascular prosthesis transluminally into a selected portion of the target blood vessel, wherein the hydrogel composition is in the non-expanded state;
- radially expanding the endovascular prosthesis into contact with the target blood vessel;
- and
- expanding the hydrogel composition to the expanded state within the target blood vessel.
A method of mediating a complication during an endovascular treatment of a target blood vessel of a patient, the method comprising:
- providing an endovascular prosthesis having a compressed configuration for delivery within a vasculature and a radially-expanded configuration for deployment within the target blood vessel, the prosthesis comprising:
- an anchor stent for engaging an inner wall of the target blood vessel when the prosthesis is in the radially-expanded configuration;
- a tubular body formed from a graft material defining a central lumen from a first end to a second end thereof, wherein the anchor stent is attached to the first end of the tubular body, the tubular body having an inner surface and an outer surface;
- a body stent attached to the outer surface of the tubular body for maintaining the tubular body in the radially-expanded configuration;
- and
- a hydrogel composition associated with about 20% to about 100% of the outer surface of the tubular body, the hydrogel composition comprising a hydrogel polymer and one or more of a stabilizing polymer, a biologically active agent and a bioabsorbable polymer, wherein the hydrogel composition in a non-expanded state and capable of expanding to an expanded state following introduction into the target blood vessel of the patient;
- introducing the endovascular prosthesis transluminally into a selected portion of the target blood vessel, wherein the hydrogel composition is in the non-expanded state;
- radially expanding the endovascular prosthesis into contact with the target blood vessel;
- and
- expanding the hydrogel composition to the expanded state within the target blood vessel, thereby mediating the complication.
Dependencies are inferred from the claim text.