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AssigneeW. L. Gore & Associates, Inc.
InventorsRobert L. Cleek, Paul D. DRUMHELLER, Theresa A. HOLLAND, Todd J. JOHNSON
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According to the invention there is provided inter alfa a medical device for delivering a therapeutic agent to a tissue, the device having a solid surfactant-free particulate coating layer applied to a surface of the device, the coating layer comprising a therapeutic agent and at least one non-polymeric organic additive which is hydrolytically stable; wherein at least a proportion of the particulate coating layer comprising the therapeutic agent and the at least one organic additive melts as a single phase at a lower temperature than the melting point of the therapeutic agent and the at least one organic additive when in pure form; wherein the therapeutic agent is paclitaxel; and wherein the therapeutic agent, when formulated in the coating layer, is stable to sterilization.
A medical device for delivering a therapeutic agent to a tissue, the device having a solid surfactant-free particulate coating layer applied to a surface of the device, the coating layer comprising a therapeutic agent and at least one non-polymeric organic additive which is hydrolytically stable;
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A medical device for delivering a therapeutic agent to a tissue, the device having a solid particulate coating layer applied to an exterior surface of the device, said surface being composed of a material selected from nylon and ePTFE, the coating layer comprising a therapeutic agent and at least one organic additive;
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A solid particulate composition comprising a therapeutic agent and at least one organic additive, wherein at least a proportion of the particulate composition comprising the therapeutic agent and at least one organic additive melts as a single phase at a lower temperature than the melting point of the therapeutic agent and the at least one organic additive when in pure form;
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Dependencies are inferred from the claim text.