Method of gene transfer for the treatment of recessive catecholaminergic polymorphic ventricular tachycardia (cpvt)

A method of treating recessive catecholaminergic polymorphic ventricular tachycardia (CPVT) in a human patient having a deleterious mutation in the gene encoding calsequestrin 2 (CASQ2) protein, said method comprising introducing a viral vector comprising a nucleic acid encoding a wild-type CASQ2 protein into a cardiac cell in said patient, wherein administration of said viral vector to said patient results in an anti-arrhythmic effect on said patient.