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US 2017/0360953 A1Published application
Binding protein drug conjugates comprising anthracycline derivatives
AssigneeNbe-Therapeutics AG
InventorsUlf Grawunder, Roger Renzo Beerli
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Abstract
The present invention relates to an anthracycline (PNU) derivative conjugate comprising a derivative of the anthracycline PNU-159682 having the formula (i) or formula (ii) which further comprises a linker structure X-L1-L2-L3-Y.
Claims26
An anthracycline (PNU) derivative conjugate or a binding protein-drug conjugate (BPDC) the same, said conjugate comprising a derivative of the anthracycline PNU-159682 having the following formula (i) or formula (ii)
- said conjugate comprising at its wavy line a linker structure X-L1-L2-L3-Y, wherein L1-L3 represent linkers, and two of L1-L3 are mandatory, and wherein X and Y further represent each one or more optional linkers.
A binding protein-drug conjugate (BPDC), having the following formula:
- wherein
- a) L1-L3 represent linkers, and two of L1-L3 are mandatory,
- b) X any Y each represent one or more optional linkers,
- c) BP is a binding protein, and
- d) n is an integer ≧1 and ≦10.
2 more elements
Dependencies are inferred from the claim text.