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US 2017/0360950 A1Published application
Drug delivery conjugates containing unnatural amino acids and methods for using
AssigneeEndocyte, Inc.
InventorsIontcho Radoslavov VLAHOV, Christopher Paul LEAMON
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Abstract
Described herein are drug delivery conjugates for targeted therapy. In particular, described herein are drug delivery conjugates that include polyvalent linkers comprising one or more unnatural amino acids that are useful for treating cancers and inflammatory diseases.
Claims21
-46. (canceled)
A compound of the formula B-L(D)x, or a pharmaceutically acceptable salt thereof, wherein B is a radical of a cell surface receptor binding ligand, D is a radical of a drug, x is 1;
- and L is a polyvalent releasable linker comprising one or more unnatural amino acids in the D-configuration;
- and where B is covalently attached to L, and L is covalently attached to D, with the proviso that the compound is not of the formula
Dependencies are inferred from the claim text.