Use of cadherin-11 antagonists to treat obesity-associated conditions and other metabolic disorders
AssigneeThe Brigham and Women's Hospital, Inc.
InventorsMichael B. Brenner, Sook Kyung Chang, Lydia Lynch
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Abstract
Provided herein are methods and pharmaceutical compositions for the treatment of obesity-associated conditions using cadherin-11 antagonists.
Claims41
A method for treating a subject having or at risk of having a metabolic disorder, comprising
- administering to a subject having or at risk of having a metabolic disorder a cadherin-11 antagonist in an effective amount to treat the metabolic disorder.
A method for treating a subject having or at risk of having an obesity-associated condition, comprising
- administering to a subject having or at risk of having an obesity-associated condition a cadherin-11 antagonist in an effective amount to treat the obesity-associated condition.
A method of treating a subject that is obese or is at risk of being obese, comprising
- administering to a subject that is obese or is at risk of being obese a cadherin-11 antagonist in an effective amount to treat or prevent an obesity-associated condition.
A pharmaceutical composition comprising a cadherin-11 antagonist for use in the treatment of a subject having or at risk of developing an obesity-associated condition.
A method for increasing insulin sensitivity index in a subject, comprising
- administering to a subject having or at risk of having an abnormal insulin sensitivity index a cadherin-11 antagonist in an effective amount to increase the subject's insulin sensitivity index.
Dependencies are inferred from the claim text.