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US 2017/0360933 A1Published application
Nucleic acid, medical nanoparticle, and pharmaceutical composition thereof
AssigneeChung Yuan Christian University
InventorsLeaf Huang, Yih-Chih Hsu, Gang Zheng, Chia-Hsien Yeh
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Abstract
A medical nanoparticle includes a core, an outer lipid layer, an inner lipid layer, a photosensitizer, and a nucleic acid. The core includes a bio-degradable ionic precipitate (BIP). The inner lipid layer is between the core and the outer lipid layer. The photosensitizer is between the inner lipid layer and the outer lipid layer, and the nucleic acid is at the surface of the core.
Claims35
A medical nanoparticle, comprising:
- a core, comprising a bio-degradable ionic precipitate (BIP);
- an outer lipid layer;
- an inner lipid layer between the core and the outer lipid layer;
- and
- a photosensitizer between the outer lipid layer and the inner lipid layer, wherein the photosensitizer is pyropheophorbide-phosphatidic acid (pyro-PA).
2 more elements
A medical nanoparticle, comprising:
- a core, comprising a bio-degradable ionic precipitate (BIP);
- an outer lipid layer;
- an inner lipid layer between the core and the outer lipid layer;
- and
- a nucleic acid at the surface of the core, wherein the nucleic acid comprises a nucleotide sequence having the sequence set forth in SEQ ID NO:
- 1.
3 more elements
A medical nanoparticle, comprising:
- a core, comprising a bio-degradable ionic precipitate (BIP);
- an outer lipid layer;
- an inner lipid layer between the core and the outer lipid layer;
- and
- a nucleic acid being capable of suppressing expressions and functions of an epidermal growth factor receptor, wherein the nucleic acid is at the surface of the core.
2 more elements
A nucleic acid, comprising a nucleotide sequence having the sequence set forth in SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.