Immune modulators in combination with radiation treatment
AssigneeVarian Medical Systems, Inc.
InventorRenate Parry
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Abstract
Methods for treating tumors by administering ionizing radiation and an immune modulator to a patient with cancer are disclosed. The methods provide the dual benefits of anti-tumor efficacy plus normal tissue protection when combining immune modulators with ionizing radiation to treat cancer patients. The methods described herein also allow for the classification of patients into groups for receiving optimized radiation treatment in combination with an immune modulator based on patient-specific biomarker signatures.
Claims31
A method for treating a tumor in a subject with cancer comprising administering an effective amount of ionizing radiation and an immune modulator to the tumor.
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A method of treating a tumor in a subject with cancer, the method comprising:
- (a) determining an expression level of one or more biomarkers in a tumor sample from the subject, wherein the one or more biomarkers are selected from the group consisting of an immune cell marker(s), tumor cell marker(s), circulating marker(s), and any combination thereof;
- (b) comparing the expression level of the one or more biomarkers to an expression level of the one or more biomarkers in a normal tissue sample;
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- (c) administering to the tumor in the subject a treatment comprising ionizing radiation and an immune modulator if the expression level of the one or more biomarkers in the tumor sample is modified compared to the expression level in the normal tissue sample
- wherein the expression level of the one or more biomarkers is modified if the expression level of at least one of the biomarkers is increased, or the expression level of at least one of the biomarkers is decreased, or the expression level of at least one of the biomarkers is increased and the expression level of at least one of the biomarkers is decreased compared to the expression level in a normal tissue sample.
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A method of selecting a treatment for a subject with cancer, the method comprising:
- (a) determining an expression level of one or more biomarkers in a tumor sample from the subject, wherein the one or more biomarkers are selected from the group consisting of an immune cell marker(s), tumor cell marker(s), circulating marker(s), and any combination thereof;
- (b) comparing the expression level of the one or more biomarkers to an expression level of the one or more biomarkers in a normal tissue sample;
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- (c) selecting a treatment comprising ionizing radiation and an immune modulator if the expression level of the one or more biomarkers in the tumor sample is modified compared to the expression level in the normal tissue sample.
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Dependencies are inferred from the claim text.