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US 2017/0360925 A1Published application
Calcium Flux Agonists And Methods Therefor
AssigneeNant Holdings IP, LLC
InventorsKayvan NIAZI, Shahrooz RABIZADEH, Justin GOLOVATO, Patrick Soon-Shiong, Anne-Laure LE NY, Oleksandr BUZKO
Life of this patent
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Abstract
Calcium flux agonists are used to enhance a TLR- or NOD-mediated stimulus and to so increase an immune response of a host and reduce healing time. Preferred calcium flux agonists include Ca2+ ionophores and SERCA inhibitors and are used in synergistic quantities where a ligand to a TLR or NOD receptor is present.
Claims12
A pharmaceutical composition comprising:
- a calcium flux agonist in a pharmaceutically acceptable carrier,
- wherein the pharmaceutical composition is formulated for topical application to injured or infected skin;
- and
- wherein the calcium flux agonist is present in an amount that enhances, upon application of the formulation to the injured or infected skin, an immune response of an immune competent cell in the injured or infected skin to a ligand of a pattern recognition receptor.
1 more element
Dependencies are inferred from the claim text.