Methods for treating and preventing cardiomyopathy
AssigneeUniversity of Washington
InventorsMichael T. CHIN, Wei-Ming CHIEN, Ana DINCA
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Abstract
Methods for treating patients having a cardiomyopathy are provided. Additionally, methods for prophylactically treating patients at risk of developing a cardiomyopathy are provided. Methods for treating patients having, or at risk of developing, a cardiomyopathy may comprise administering a fusion protein including a tafazzin peptide and a cellular permeability peptide to the patient. Further, the tafazzin peptide may be coupled to the cellular permeability peptide by a polypeptide linker.
Claims30
A method for treating a subject having a cardiomyopathy, comprising:
- administering to the subject a fusion protein comprising a tafazzin peptide and a cellular permeability peptide.
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A method for treating a patient having a cardiomyopathy, comprising:
- administering to the patient an effective amount of a pharmaceutical composition comprising:
- a fusion protein comprising a tafazzin peptide and a cellular permeability peptide;
- and
- a pharmaceutically acceptable carrier
- to reduce a pathological effect or symptom of the cardiomyopathy.
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A method for prophylactically treating a patient at a risk of developing a cardiomyopathy, comprising:
- administering to the patient an effective amount of a pharmaceutical composition comprising:
- a fusion protein comprising a tafazzin peptide and a cellular permeability peptide;
- and
- a pharmaceutically acceptable carrier to reduce the risk of developing the cardiomyopathy.
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Dependencies are inferred from the claim text.