Methods for treating immune-mediated viral infections
AssigneeMiddle Tennessee State University
InventorsNeil M. Bodie, Hyo Park, Elliot Altman
Life of this patent
Estimating the term…
Abstract
Polypeptides and other compounds that can bind specifically to the CH2-CH3 cleft of an immunoglobulin molecule, as well as methods for using such polypeptides and compounds to inhibit Fc-mediated immune complex formation in viral infection, I are described. For example, polypeptides and other compounds can be used to inhibit immune complex formation in a subject who has been diagnosed as having or is suspected of having an Ebola virus infection, a subject who has been diagnosed as having or is suspected of having an influenza virus infection, or a subject who has been diagnosed as having or is suspected of having a hepatitis virus infection.
Claims27
A method for inhibiting immune complex formation in a subject who has been diagnosed as having or is suspected of having an Ebola virus infection, said method comprising administering to said subject a composition comprising a purified polypeptide, said polypeptide comprising the amino acid sequence Xaa-Pro-Pro-Asp-Cys-Ala-Trp-His-Leu-Gly-Glu-Leu-Val-Trp-Cys-Thr (SEQ ID NO:
- 19), wherein Xaa is any amino acid, and wherein said immune complex formation is associated with Antibody Dependent Enhancement (ADE) of Ebola Virus Disease or infection by Ebola Virus (EBOV), or contributes to the enhancement of an EBOV infection.
(canceled)
(canceled)
-14. (canceled)
-21. (canceled)
A method for inhibiting immune complex formation in a subject who has been diagnosed as having or is suspected of having an influenza virus infection, said method comprising administering to said subject a composition comprising a purified polypeptide, said polypeptide comprising the amino acid sequence Xaa-Pro-Pro-Asp-Cys-Ala-Trp-His-Leu-Gly-Glu-Leu-Val-Trp-Cys-Thr (SEQ ID NO:
- 19), wherein Xaa is any amino acid, and wherein said immune complex formation contributes to the enhancement of an influenza virus infection.
(canceled)
27-31. (canceled)
A method for inhibiting immune complex formation in a subject who has been diagnosed as having or is suspected of having a hepatitis virus infection, said method comprising administering to said subject a composition comprising a purified polypeptide, said polypeptide comprising the amino acid sequence Xaa-Pro-Pro-Asp-Cys-Ala-Trp-His-Leu-Gly-Glu-Leu-Val-Trp-Cys-Thr (SEQ ID NO:
- 19), wherein Xaa is any amino acid, and wherein said immune complex formation contributes to the enhancement of a hepatitis virus infection.
-40. (canceled)
Dependencies are inferred from the claim text.