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AssigneeArizona Board of Regents on behalf of Arizona State University
InventorsJames ADAMS, Dae-Wook KANG, Rosa KRAJMALNIK-BROWN
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The present disclosure relates to compositions and methods for treating autism spectrum disorder (ASD) by restoring an ASD patient's gut microbiota. These methods can be used with ASD patient with or without ongoing gastrointestinal symptoms. Provided here is a method for modulating the abundance of one or more gut microorganisms in a subject in need thereof, said method comprising administering to said subject a therapeutically effective amount of a pharmaceutical composition comprising a fecal microbe preparation to achieve at least a 2-fold change of the abundance of said one or more gut microorganisms, wherein said one or more gut microorganisms are selected from the group consisting of Bifidobacterium, Prevotella, Desulfovibrio, Copprococcus, Clostridium, and Bacteroides.
A method for increasing the abundance of one or more gut microorganisms in a subject in need thereof, said method comprising treating said subject by administering a therapeutically effective amount of a pharmaceutical composition comprising a fecal microbe preparation comprising a substantially complete fecal microbiota from a single donor, wherein said subject exhibits at least a 2-fold increase of the abundance of said one or more gut microorganisms after said treatment as compared to before initiating said treatment, wherein said one or more gut microorganisms are selected from the group consisting of Bifidobacterium, Prevotella and Desulfovibrio.
A method for modulating the abundance of one or more gut microorganisms in a subject in need thereof, said method comprising treating said subject by administering a therapeutically effective amount of a pharmaceutical composition comprising a fecal microbe preparation comprising a substantially complete fecal microbiota from a single donor, wherein said subject exhibits at least a 2-fold change of the abundance of said one or more gut microorganisms after said treatment as compared to before initiating said treatment, wherein said one or more gut microorganisms are selected from the group consisting of Bifidobacterium, Prevotella, Desulfovibrio, Copprococcus, Clostridium, Eggerthella, and Bacteroides.
A method comprising
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