Cyclic di-amp induction of type i interferon
AssigneeThe Regents of the University of California
InventorsDaniel A. Portnoy, Joshua J. Woodward
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Abstract
Methods of modulating type-I interferon production in a cell are provided. Aspects of the methods include modulating cytosolic cyclic di-adenosine monophosphate (c-di-AMP) activity in the cell in a manner sufficient to modulate type-I interferon production in the cell. Additional aspects of the invention include c-di-AMP activity modulatory compositions, e.g., c-di-AMP, mutant Listeria bacteria, cyclase and/or phosphodiesterase nucleic acid or protein compositions, etc. The subject methods and compositions find use in a variety of applications, including therapeutic applications.
Claims60
A method of modulating type-I interferon production in a eukaryotic cell, the method comprising:
- modulating cytosolic cyclic di-adenosine monophosphate (c-di-AMP) activity in the eukaryotic cell in a manner sufficient to modulate type-I interferon production in the cell.
A mutant Listeria bacterium comprising a mutation which modulates secretion of a compound selected from the group consisting of:
- c-di-AMP;
- cytosolic di-adenylate cyclase and c-di-AMP phosphodiesterase and combinations thereof;
- as compared to its corresponding wild-type control.
Dependencies are inferred from the claim text.