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US 2017/0360844 A1Published application
Use of anti-aging glycopeptides to enhance pancreatic cell health survival and improve transplant outcome
AssigneeProtokinetix Inc.
InventorsLachlan Grant Young, A.M. James Shapiro
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Abstract
The present disclosure relates to an in vitro method for enhancing engraftment of isolated pancreatic cells comprising the step of contacting an isolated pancreatic cell prior to a transplantation in a subject in need thereof, with a gem-difluorinated C-glycopeptide compound of general formula I, or a pharmaceutically acceptable base, addition salt with an acid, hydrate or solvate of the compound of general formula I:
Claims17
-18. (canceled)
A method for enhancing engraftment of isolated pancreatic cells, isolated pancreatic progenitor cells, or both comprising the step of:
- a) contacting an isolated pancreatic cell, an isolated pancreatic progenitor cell, or both prior to a transplantation in a subject in need thereof, with a gem-difluorinated C-glycopeptide compound of formula III, or a pharmaceutically acceptable base, addition salt with an acid, hydrate or solvate thereof, and then washing the isolated pancreatic cell, the isolated pancreatic progenitor cell, or both to remove the compound:
Dependencies are inferred from the claim text.