Materials and methods for treating endothelial dysfunction and methods for monitoring efficacy of therapy in a subject
AssigneeUniversity of Miami
InventorsJoshua M. Hare, Courtney Premer, Arnon Blum
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Abstract
The present disclosure is directed to materials and methods for treating endothelial dysfunction in a subject in need thereof. Methods of determining efficacy of treatment are also provided.
Claims11
A method of monitoring efficacy of a therapy for endothelial dysfunction in a subject comprising
- determining levels of Vascular Endothelial Growth Factor (VEGF) and endothelial progenitor cells (EPCs) in a first sample from the subject before administration of a therapy for endothelial dysfunction;
- and
- determining levels of VEGF and EPCs in a second sample from the subject after administration of a therapy for endothelial dysfunction;
- wherein a decreased level of VEGF in the sample and an increased level of EPCs in the second sample compared to the levels of VEGF and EPC in the first sample is indicative of effective treatment of the endothelial dysfunction.
A method of monitoring efficacy of mesenchymal stem cell therapy in a subject suffering from a cardiovascular disorder comprising determining a level of Vascular Endothelial Growth Factor (VEGF) in a sample from the subject after administration of the stem cell therapy, and comparing the level of VEGF to a predetermined criterion.
A method of treating endothelial dysfunction in a subject in need thereof comprising administering to a subject allogeneic mesenchymal stem cells in an amount effect to decrease circulating levels of Vascular Endothelial Growth Factor and increase levels of endothelial progenitor cells in the subject, thereby treating the endothelial dysfunction.
Dependencies are inferred from the claim text.