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US 2017/0360794 A1Published application
Jak inhibitor
AssigneeWuxi Fortune Pharmaceutical Co., Ltd
InventorsHao WU, Weiwei MAO, Lili FAN, Charles Z. DING, Shuhui CHEN, Fei WANG, Guoping HU, Jian LI
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Abstract
The present invention discloses a series of JAK inhibitors, and particularly discloses a compound of formula (I) or a pharmaceutically acceptable salt thereof and the use thereof in preparation of drugs for treating diseases related to JAK.
Claims10
A compound of formula (I) or a pharmaceutically acceptable salt thereof,
- wherein,
- ring A is selected from optionally substituted:
- 5˜12 membered heterocycloalkyl or 5˜6 membered heteroaryl;
- R1 is selected from H or optionally substituted C1-6 alkyl, C1-6 heteroalkyl, C3-6 cycloalkyl, 3˜6 membered heterocycloalkyl, 5˜6 membered aryl, or 5˜6 membered heteroaryl;
- L is selected from single bond, —C(═O)O—, acyl or optionally substituted:
- amino, aminoacyl, acyl amino methylene and aminoacyl methylene;
- optionally, R1 and the N in L forms a optionally substituted 3˜6 membered ring;
- R2 is selected from H, or optionally substituted C1-3 alkyl and 3˜6 membered cycloalkyl;
- optionally, the structural unit
- can be replaced by
- and “hetero” indicates O, S or NO, and the number is selected from 1, 2 or 3.
8 more elements
Dependencies are inferred from the claim text.